HCSGD entry for GSTP1

1. General information

Official gene symbolGSTP1
Entrez ID2950
Gene full nameglutathione S-transferase pi 1
Other gene symbolsDFN7 FAEES3 GST3 GSTP PI
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000302Response to reactive oxygen speciesISSbiological_process
GO:0002674Negative regulation of acute inflammatory responseNASbiological_process
GO:0004364Glutathione transferase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIDAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006469Negative regulation of protein kinase activityIDAbiological_process
GO:0006749Glutathione metabolic processIDAbiological_process
GO:0006805Xenobiotic metabolic processIDA TASbiological_process
GO:0007417Central nervous system developmentTASbiological_process
GO:0008432JUN kinase bindingISSmolecular_function
GO:0009890Negative regulation of biosynthetic processIDAbiological_process
GO:0010804Negative regulation of tumor necrosis factor-mediated signaling pathwayICbiological_process
GO:0019207Kinase regulator activityISSmolecular_function
GO:0032691Negative regulation of interleukin-1 beta productionIDAbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIDAbiological_process
GO:0032872Regulation of stress-activated MAPK cascadeISSbiological_process
GO:0032873Negative regulation of stress-activated MAPK cascadeISSbiological_process
GO:0032930Positive regulation of superoxide anion generationISSbiological_process
GO:0035726Common myeloid progenitor cell proliferationISSbiological_process
GO:0035730S-nitrosoglutathione bindingIDAmolecular_function
GO:0035731Dinitrosyl-iron complex bindingIDAmolecular_function
GO:0035732Nitric oxide storageNASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043124Negative regulation of I-kappaB kinase/NF-kappaB signalingISSbiological_process
GO:0043407Negative regulation of MAP kinase activityIDAbiological_process
GO:0043409Negative regulation of MAPK cascadeNASbiological_process
GO:0043508Negative regulation of JUN kinase activityIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0048147Negative regulation of fibroblast proliferationISSbiological_process
GO:0051771Negative regulation of nitric-oxide synthase biosynthetic processIDAbiological_process
GO:0060547Negative regulation of necrotic cell deathISSbiological_process
GO:0070026Nitric oxide bindingNASmolecular_function
GO:0070372Regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0070373Negative regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0070664Negative regulation of leukocyte proliferationISSbiological_process
GO:0071222Cellular response to lipopolysaccharideISSbiological_process
GO:0071638Negative regulation of monocyte chemotactic protein-1 productionIDAbiological_process
GO:0097057TRAF2-GSTP1 complexIDAcellular_component
GO:1901687Glutathione derivative biosynthetic processTASbiological_process
GO:2001237Negative regulation of extrinsic apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.88272442920.08634220960.99999024730.5579703658

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1369359152
GSE13712_SHEARDown-0.2921323966
GSE13712_STATICDown-0.2501396976
GSE19018Up0.2829528211
GSE19899_A1Down-0.3697429077
GSE19899_A2Down-0.1774686795
PubMed_21979375_A1Down-0.1724775968
PubMed_21979375_A2Down-0.3137578929
GSE35957Down-0.7573901595
GSE36640Down-0.1829115229
GSE54402Up0.3324324276
GSE9593Up0.0054797148
GSE43922Down-0.0116221851
GSE24585Down-0.3141481112
GSE37065Down-0.0196214023
GSE28863_A1Down-0.2933847158
GSE28863_A2Down-0.3869097662
GSE28863_A3Up0.1447709012
GSE28863_A4Up0.1242083629
GSE48662Up0.1252818206

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GlutathioneDB00143 NUTR00029 | EXPT01650
(9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-DihydrophenanthreneDB01834 EXPT01641
S-HydroxycysteineDB01915 EXPT01035 | DB03398
Cibacron BlueDB02633 EXPT00841
Glutathione Sulfonic AcidDB03003 EXPT01662
S-(P-Nitrobenzyl)GlutathioneDB03686 EXPT01653
2-(N-Morpholino)-Ethanesulfonic AcidDB03814 EXPT02154
GlycerolDB04077 EXPT01027
S-HexylglutathioneDB04132 EXPT01664
CarbocisteineDB04339 EXPT00835 | DB02476
CanfosfamideDB04972 -
TLK-199DB05460 -
S-NONYL-CYSTEINEDB07849 -
S-(4-BROMOBENZYL)CYSTEINEDB08370 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-513a-3pMIMAT0004777MIRT006966Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22749944
hsa-miR-133a-3pMIMAT0000427MIRT021715Reporter assay;MicroarrayFunctional MTI21396852
hsa-miR-26b-5pMIMAT0000083MIRT029320MicroarrayFunctional MTI (Weak)19088304
hsa-miR-92a-3pMIMAT0000092MIRT049201CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23401708Pummelo protects Doxorubicin-induced cardiac cell death by reducing oxidative stress, modifying glutathione transferase expression, and preventing cellular senescence
10092208In contrast with plastic cultures, cells responded to CYP450 inducers (methylcholanthrene for CYP4501A1, CYP4501A2, and glutathione-transferase, and ethanol for CYP4502E1) for more than 2 weeks
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