HCSGD entry for GTF2H3

1. General information

Official gene symbolGTF2H3
Entrez ID2967
Gene full namegeneral transcription factor IIH, polypeptide 3, 34kDa
Other gene symbolsBTF2 P34 TFB4 TFIIH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000439Core TFIIH complexIEAcellular_component
GO:0000718Nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0003684Damaged DNA bindingTASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityNASmolecular_function
GO:0004672Protein kinase activityIDAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005675Holo TFIIH complexIDAcellular_component
GO:0006200ATP catabolic processIDAbiological_process
GO:0006281DNA repairTASbiological_process
GO:0006283Transcription-coupled nucleotide-excision repairTASbiological_process
GO:0006289Nucleotide-excision repairIEA TASbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006360Transcription from RNA polymerase I promoterTASbiological_process
GO:0006361Transcription initiation from RNA polymerase I promoterTASbiological_process
GO:0006362Transcription elongation from RNA polymerase I promoterTASbiological_process
GO:0006363Termination of RNA polymerase I transcriptionTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDA TASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006368Transcription elongation from RNA polymerase II promoterTASbiological_process
GO:00063707-methylguanosine mRNA cappingTASbiological_process
GO:0006412TranslationTASbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0008094DNA-dependent ATPase activityIDAmolecular_function
GO:0008135Translation factor activity, nucleic acid bindingTASmolecular_function
GO:0008353RNA polymerase II carboxy-terminal domain kinase activityIDAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016310PhosphorylationIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0047485Protein N-terminus bindingIPImolecular_function
GO:0050434Positive regulation of viral transcriptionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93116990620.04308845410.99999024730.3906755770

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1530216779
GSE13712_SHEARUp0.3895946990
GSE13712_STATICUp0.2107617044
GSE19018Down-0.3282481187
GSE19899_A1Down-0.4482195606
GSE19899_A2Up0.1765282552
PubMed_21979375_A1Down-0.6136182867
PubMed_21979375_A2Down-0.2677850600
GSE35957Down-0.2586216402
GSE36640Down-0.2554495910
GSE54402Up0.2207605378
GSE9593Down-0.3185793081
GSE43922Up0.0028044886
GSE24585Down-0.0769787811
GSE37065Down-0.2905997692
GSE28863_A1Down-0.4773731058
GSE28863_A2Down-0.2816291814
GSE28863_A3Down-0.5530368130
GSE28863_A4Up0.2939711049
GSE48662Up0.0314384602

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-33a-5pMIMAT0000091MIRT028194SequencingFunctional MTI (Weak)20371350
hsa-miR-484MIMAT0002174MIRT042315CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.