HCSGD entry for GTF2I
1. General information
| Official gene symbol | GTF2I |
|---|---|
| Entrez ID | 2969 |
| Gene full name | general transcription factor IIi |
| Other gene symbols | BAP135 BTKAP1 DIWS GTFII-I IB291 SPIN TFII-I WBS WBSCR6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0009790 | Embryo development | IEA | biological_process |
| GO:0016525 | Negative regulation of angiogenesis | IDA | biological_process |
| GO:0042995 | Cell projection | IEA | cellular_component |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0051019 | Mitogen-activated protein kinase binding | IEA | molecular_function |
| GO:0051481 | Negative regulation of cytosolic calcium ion concentration | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9081716918 | 0.0186186087 | 0.9999902473 | 0.2674027823 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0655943121 |
| GSE13712_SHEAR | Up | 0.0336181992 |
| GSE13712_STATIC | Down | -0.2240223082 |
| GSE19018 | Up | 0.1839827521 |
| GSE19899_A1 | Down | -0.3492351879 |
| GSE19899_A2 | Down | -0.2284240623 |
| PubMed_21979375_A1 | Down | -1.2513171498 |
| PubMed_21979375_A2 | Down | -1.8597726139 |
| GSE35957 | Up | 0.4565275655 |
| GSE36640 | Down | -0.4310302399 |
| GSE54402 | Down | -0.5479576883 |
| GSE9593 | Up | 0.2128958786 |
| GSE43922 | Down | -0.5249122239 |
| GSE24585 | Up | 0.2089923896 |
| GSE37065 | Down | -0.1380735680 |
| GSE28863_A1 | Down | -0.0108388494 |
| GSE28863_A2 | Up | 0.0925165616 |
| GSE28863_A3 | Down | -0.3101525254 |
| GSE28863_A4 | Down | -0.3122951635 |
| GSE48662 | Up | 0.1080557841 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT005058 | Microarray | Functional MTI (Weak) | 17699775 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030772 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036317 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-3p | MIMAT0004555 | MIRT038672 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042033 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046376 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048674 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051501 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052433 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
