HCSGD entry for NPC1L1

1. General information

Official gene symbolNPC1L1
Entrez ID29881
Gene full nameNPC1-like 1
Other gene symbolsNPC11L1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006695Cholesterol biosynthetic processIMPbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0008158Hedgehog receptor activityIEAmolecular_function
GO:0015918Sterol transportTASbiological_process
GO:0016021Integral component of membraneIDA IEAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0017137Rab GTPase bindingIPImolecular_function
GO:0030299Intestinal cholesterol absorptionIMPbiological_process
GO:0030301Cholesterol transportIMPbiological_process
GO:0030659Cytoplasmic vesicle membraneIEAcellular_component
GO:0031489Myosin V bindingIPImolecular_function
GO:0031526Brush border membraneIEAcellular_component
GO:0042157Lipoprotein metabolic processIMPbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.49882985070.94264604310.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0000617710
GSE13712_SHEARUp0.0838166181
GSE13712_STATICUp0.0129015381
GSE19018Up0.0226931175
GSE19899_A1Up0.0160767234
GSE19899_A2Up0.1423205697
PubMed_21979375_A1Down-0.0130365135
PubMed_21979375_A2Up0.1110926539
GSE35957Up0.0747543928
GSE36640Up0.0501497893
GSE54402Up0.0189830520
GSE9593Down-0.0353498030
GSE43922Up0.0412288298
GSE24585Down-0.0851637317
GSE37065Up0.1017709342
GSE28863_A1Down-0.0191147086
GSE28863_A2Up0.1703550459
GSE28863_A3Up0.3079731466
GSE28863_A4Up0.1108973091
GSE48662Up0.0415517574

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

EzetimibeDB00973 APRD00619

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.