HCSGD entry for CERS2
1. General information
| Official gene symbol | CERS2 |
|---|---|
| Entrez ID | 29956 |
| Gene full name | ceramide synthase 2 |
| Other gene symbols | L3 LASS2 SP260 TMSG1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030148 | Sphingolipid biosynthetic process | TAS | biological_process |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046513 | Ceramide biosynthetic process | IEA | biological_process |
| GO:0050291 | Sphingosine N-acyltransferase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0272625546 | 0.9476709927 | 0.3833214209 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6089761161 |
| GSE13712_SHEAR | Down | -0.0910707451 |
| GSE13712_STATIC | Down | -0.0019325586 |
| GSE19018 | Down | -0.1079528531 |
| GSE19899_A1 | Up | 0.6311118230 |
| GSE19899_A2 | Up | 0.6624875427 |
| PubMed_21979375_A1 | Up | 0.4951910755 |
| PubMed_21979375_A2 | Up | 0.7875539670 |
| GSE35957 | Down | -0.2504493485 |
| GSE36640 | Up | 0.9093682772 |
| GSE54402 | Up | 0.2766193448 |
| GSE9593 | Up | 0.1907910157 |
| GSE43922 | Up | 0.2839401672 |
| GSE24585 | Down | -0.0850844629 |
| GSE37065 | Up | 0.0615234548 |
| GSE28863_A1 | Up | 0.2055628082 |
| GSE28863_A2 | Up | 0.4765907842 |
| GSE28863_A3 | Down | -0.0035043465 |
| GSE28863_A4 | Down | -0.3532486431 |
| GSE48662 | Down | -0.1427208640 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002726 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002726 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT002754 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT002754 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT006917 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22393241 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT006918 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22393241 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021462 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-133a-3p | MIMAT0000427 | MIRT021707 | Microarray | Functional MTI (Weak) | 21396852 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027344 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028158 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-625-5p | MIMAT0003294 | MIRT039594 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050621 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22230369 | Recently, we demonstrated that human breast cancer tissue displays increased activity of CerS2, 4, and 6, together with enhanced generation of their products, ceramides C(16:0), C(24:0), and C(24:1) |
| 22230369 | Overexpression of ceramide synthases 4 and 6 elevated generation of short chain ceramides C(16:0), C(18:0) and C(20:0), while overexpression of ceramide synthase 2 had no effect on ceramide production in vivo, presumably due to limited substrate availability, because external addition of very long chain acyl-CoAs resulted in a significant upregulation of very long chain ceramides |
| 18369446 | 1/SIRT1 and lagr-1/LASS2 |
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