HCSGD entry for TBX21
1. General information
| Official gene symbol | TBX21 |
|---|---|
| Entrez ID | 30009 |
| Gene full name | T-box 21 |
| Other gene symbols | T-PET T-bet TBET TBLYM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0009615 | Response to virus | IEP | biological_process |
| GO:0030217 | T cell differentiation | IEA | biological_process |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0048304 | Positive regulation of isotype switching to IgG isotypes | IEA | biological_process |
| GO:0072676 | Lymphocyte migration | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0361970290 | 0.9066712587 | 0.4322785844 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0702285116 |
| GSE13712_SHEAR | Down | -0.0270647267 |
| GSE13712_STATIC | Down | -0.0628335253 |
| GSE19018 | Down | -0.1159306968 |
| GSE19899_A1 | Up | 0.2120318088 |
| GSE19899_A2 | Up | 0.6500980312 |
| PubMed_21979375_A1 | Up | 1.5674588687 |
| PubMed_21979375_A2 | Up | 0.8150770412 |
| GSE35957 | Up | 0.0834360201 |
| GSE36640 | Down | -0.0798255144 |
| GSE54402 | Up | 1.7104202606 |
| GSE9593 | Down | -0.0355044960 |
| GSE43922 | Up | 0.1604616060 |
| GSE24585 | Up | 0.1483801035 |
| GSE37065 | Down | -0.0667251641 |
| GSE28863_A1 | Down | -0.3318038792 |
| GSE28863_A2 | Down | -0.2822179264 |
| GSE28863_A3 | Up | 0.4968134865 |
| GSE28863_A4 | Up | 0.1514979730 |
| GSE48662 | Up | 0.0957095326 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29b-3p | MIMAT0000100 | MIRT007033 | Luciferase reporter assay | Functional MTI | 22772450 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24925089 | JMJD3 also interacts with T-bet factor and induces Th1 differentiation of CD4(+) T cells |
| 16204645 | Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells |
| 16204645 | In CD8+ T cells and NK cells, the transcription factors T-bet and eomesodermin (Eomes) regulate maturation and effector functions, including IFN-gamma production |
| 16204645 | Implantation sites in T-bet null mice, which have a defect in NK cell maturation, had uNK cells normal in morphology and number and normally modified spiral arteries |
| 16204645 | As Eomes null mice are not viable, real-time polymerase chain reaction comparisons between C57Bl/6J (B6) and alymphoid (Rag2(0/0)gammac0/0) mice were used to assess uNK cell expression of T-bet, Eomes, and the target genes IFN-gamma, granzyme A, and perforin |
| 16204645 | In uterus, Eomes transcripts greatly outnumbered those of T-bet, whether donors were nonpregnant or pregnant, and increased to gd10 |
| 16204645 | In uNK cells, transcripts for T-bet, Eomes, and IFN-gamma were most abundant in mature stage cells, and transcripts for granzyme A and perforin were lower at this stage than in immature or senescent cells |
| 16204645 | Thus, Eomes dominance to T-bet discriminates regulation of the uNK cell subset from that observed for peripheral NK cells |
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