HCSGD entry for ANXA2
1. General information
| Official gene symbol | ANXA2 |
|---|---|
| Entrez ID | 302 |
| Gene full name | annexin A2 |
| Other gene symbols | ANX2 ANX2L4 CAL1H LIP2 LPC2 LPC2D P36 PAP-IV |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA IEP | biological_process |
| GO:0001726 | Ruffle | IEA | cellular_component |
| GO:0001934 | Positive regulation of protein phosphorylation | IEA | biological_process |
| GO:0004859 | Phospholipase inhibitor activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005544 | Calcium-dependent phospholipid binding | IDA IEA | molecular_function |
| GO:0005546 | Phosphatidylinositol-4,5-bisphosphate binding | IEA | molecular_function |
| GO:0005604 | Basement membrane | IEA | cellular_component |
| GO:0005769 | Early endosome | IEA | cellular_component |
| GO:0005811 | Lipid particle | IDA | cellular_component |
| GO:0005938 | Cell cortex | IEA | cellular_component |
| GO:0007589 | Body fluid secretion | IEA | biological_process |
| GO:0008092 | Cytoskeletal protein binding | IEA | molecular_function |
| GO:0017137 | Rab GTPase binding | IEA | molecular_function |
| GO:0019897 | Extrinsic component of plasma membrane | IEA | cellular_component |
| GO:0030199 | Collagen fibril organization | IEA | biological_process |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0031012 | Extracellular matrix | ISS | cellular_component |
| GO:0031340 | Positive regulation of vesicle fusion | IDA | biological_process |
| GO:0031982 | Vesicle | IEA | cellular_component |
| GO:0035749 | Myelin sheath adaxonal region | IEA | cellular_component |
| GO:0042383 | Sarcolemma | IEA | cellular_component |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0042730 | Fibrinolysis | IEA | biological_process |
| GO:0043220 | Schmidt-Lanterman incisure | IEA | cellular_component |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0044354 | Macropinosome | IEA | cellular_component |
| GO:0048146 | Positive regulation of fibroblast proliferation | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0051099 | Positive regulation of binding | IEA | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
| GO:0071229 | Cellular response to acid | IEA | biological_process |
| GO:0072661 | Protein targeting to plasma membrane | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3894452946 | 0.6216966643 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1236842579 |
| GSE13712_SHEAR | Up | 0.2477594952 |
| GSE13712_STATIC | Up | 0.2409301902 |
| GSE19018 | Up | 0.3517683498 |
| GSE19899_A1 | Up | 0.0053459888 |
| GSE19899_A2 | Up | 0.0489820517 |
| PubMed_21979375_A1 | Up | 0.7222016918 |
| PubMed_21979375_A2 | Down | -0.2306590873 |
| GSE35957 | Down | -0.0041482780 |
| GSE36640 | Down | -0.2246621529 |
| GSE54402 | Up | 0.0889136096 |
| GSE9593 | Up | 0.1333249814 |
| GSE43922 | Up | 0.0564768807 |
| GSE24585 | Up | 0.0454578755 |
| GSE37065 | Down | -0.2266650595 |
| GSE28863_A1 | Down | -0.0506853685 |
| GSE28863_A2 | Down | -0.3459930261 |
| GSE28863_A3 | Down | -0.2978270911 |
| GSE28863_A4 | Up | 0.1428731007 |
| GSE48662 | Down | -0.2202624390 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Tenecteplase | DB00031 | BTD00019 | BIOD00019 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001388 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT001388 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020897 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039126 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT045844 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23969227 | Stringent reduction of the extensive proteomic data from this tumor cell model revealed a list of 59 markers including proteins identified in our former studies and a number of novel proteins involved in tumorigenesis and metastasis such as SFN, S100A4, ANXA2, and LGALS1 |
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