HCSGD entry for HAGH
1. General information
| Official gene symbol | HAGH |
|---|---|
| Entrez ID | 3029 |
| Gene full name | hydroxyacylglutathione hydrolase |
| Other gene symbols | GLO2 GLX2 GLXII HAGH1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004416 | Hydroxyacylglutathione hydrolase activity | IDA IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IDA IEA | cellular_component |
| GO:0006750 | Glutathione biosynthetic process | IDA IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0015108583 | 0.9960922875 | 0.1045895013 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2449293863 |
| GSE13712_SHEAR | Down | -0.0128042169 |
| GSE13712_STATIC | Up | 0.0765500337 |
| GSE19018 | Up | 0.6539675304 |
| GSE19899_A1 | Up | 0.5003277435 |
| GSE19899_A2 | Up | 1.6896353281 |
| PubMed_21979375_A1 | Up | 1.3833524591 |
| PubMed_21979375_A2 | Up | 0.3698371806 |
| GSE35957 | Up | 0.1528416856 |
| GSE36640 | Up | 2.3683230838 |
| GSE54402 | Up | 0.4891517992 |
| GSE9593 | Up | 0.7915633610 |
| GSE43922 | Up | 0.3296277951 |
| GSE24585 | Up | 0.5459209129 |
| GSE37065 | Up | 0.0432870930 |
| GSE28863_A1 | Up | 0.0339007580 |
| GSE28863_A2 | Up | 0.2196417825 |
| GSE28863_A3 | Up | 0.5527690434 |
| GSE28863_A4 | Up | 0.0340905573 |
| GSE48662 | Up | 0.3622498265 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Glutathione | DB00143 | NUTR00029 | EXPT01650 |
| S-(N-Hydroxy-N-Bromophenylcarbamoyl)Glutathione | DB03889 | EXPT01552 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029772 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040597 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30d-5p | MIMAT0000245 | MIRT047796 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 3994738 | It was metabolized by glyoxalase I with reduced glutathione to S-glyceroyl glutathione which was subsequently enzymatically hydrolyzed to reduced glutathione and glycerate by glyoxalase II |
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