HCSGD entry for HADHB

1. General information

Official gene symbolHADHB
Entrez ID3032
Gene full namehydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
Other gene symbolsECHB MTPB TP-BETA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000062Fatty-acyl-CoA bindingIEAmolecular_function
GO:00038573-hydroxyacyl-CoA dehydrogenase activityTASmolecular_function
GO:0003988Acetyl-CoA C-acyltransferase activityIEAmolecular_function
GO:0004300Enoyl-CoA hydratase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionNAScellular_component
GO:0005740Mitochondrial envelopeTAScellular_component
GO:0005741Mitochondrial outer membraneIDAcellular_component
GO:0005743Mitochondrial inner membraneIDA IEA TAScellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0006635Fatty acid beta-oxidationIEA TASbiological_process
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0016507Mitochondrial fatty acid beta-oxidation multienzyme complexIEAcellular_component
GO:0016508Long-chain-enoyl-CoA hydratase activityIEAmolecular_function
GO:0016509Long-chain-3-hydroxyacyl-CoA dehydrogenase activityIEAmolecular_function
GO:0016747Transferase activity, transferring acyl groups other than amino-acyl groupsIEAmolecular_function
GO:0032403Protein complex bindingIEAmolecular_function
GO:0035965Cardiolipin acyl-chain remodelingTASbiological_process
GO:0042645Mitochondrial nucleoidIDAcellular_component
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046474Glycerophospholipid biosynthetic processTASbiological_process
GO:0051287NAD bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06370033050.94722716840.54419227521.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3875761144
GSE13712_SHEARDown-0.1825580311
GSE13712_STATICDown-0.0702700328
GSE19018Up0.4334503829
GSE19899_A1Up0.5364993339
GSE19899_A2Up0.5351160785
PubMed_21979375_A1Up0.5186105115
PubMed_21979375_A2Up0.3746884743
GSE35957Down-0.0707136708
GSE36640Up0.4414427287
GSE54402Up0.2066699285
GSE9593Up0.1267546304
GSE43922Up0.1005654806
GSE24585Up0.0223085302
GSE37065Down-0.0826445301
GSE28863_A1Up0.2046264179
GSE28863_A2Up0.2679401100
GSE28863_A3Down-0.3405773401
GSE28863_A4Down-0.2140705814
GSE48662Down-0.1972969279

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT002711ProteomicsFunctional MTI (Weak)18668037
hsa-miR-124-3pMIMAT0000422MIRT002711MicroarrayFunctional MTI (Weak)15685193
hsa-miR-193b-3pMIMAT0002819MIRT016498ProteomicsFunctional MTI (Weak)21512034
hsa-miR-1229-3pMIMAT0005584MIRT036297CLASHFunctional MTI (Weak)23622248
hsa-miR-99a-5pMIMAT0000097MIRT048639CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.