HCSGD entry for HDGF
1. General information
| Official gene symbol | HDGF |
|---|---|
| Entrez ID | 3068 |
| Gene full name | hepatoma-derived growth factor |
| Other gene symbols | HMG1L2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0001106 | RNA polymerase II transcription corepressor activity | IDA | molecular_function |
| GO:0001222 | Transcription corepressor binding | IPI | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0008083 | Growth factor activity | IEA | molecular_function |
| GO:0008201 | Heparin binding | IEA | molecular_function |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0017053 | Transcriptional repressor complex | IDA | cellular_component |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0938163444 | 0.3641923673 | 0.6418871848 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1802230163 |
| GSE13712_SHEAR | Up | 0.1741924749 |
| GSE13712_STATIC | Down | -0.0998477190 |
| GSE19018 | Up | 0.2656261220 |
| GSE19899_A1 | Up | 0.5657128252 |
| GSE19899_A2 | Up | 0.5160232682 |
| PubMed_21979375_A1 | Up | 1.1738122780 |
| PubMed_21979375_A2 | Up | 0.9528918489 |
| GSE35957 | Down | -0.8780339698 |
| GSE36640 | Down | -1.0995365040 |
| GSE54402 | Up | 0.6798357251 |
| GSE9593 | Down | -0.2821328649 |
| GSE43922 | Up | 0.1285859320 |
| GSE24585 | Down | -0.2896740262 |
| GSE37065 | Down | -0.2951391702 |
| GSE28863_A1 | Down | -0.1738027347 |
| GSE28863_A2 | Up | 0.0961655807 |
| GSE28863_A3 | Down | -0.1947955705 |
| GSE28863_A4 | Down | -0.1823487191 |
| GSE48662 | Up | 0.2195496044 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29c-3p | MIMAT0000681 | MIRT020405 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036027 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-671-3p | MIMAT0004819 | MIRT037776 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039959 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-503-5p | MIMAT0002874 | MIRT041133 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-501-5p | MIMAT0002872 | MIRT041137 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041514 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20b-5p | MIMAT0001413 | MIRT042399 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045146 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046076 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046638 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048885 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049138 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT049930 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
