HCSGD entry for HDLBP
1. General information
| Official gene symbol | HDLBP |
|---|---|
| Entrez ID | 3069 |
| Gene full name | high density lipoprotein binding protein |
| Other gene symbols | HBP PRO2900 VGL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006869 | Lipid transport | IEA | biological_process |
| GO:0008203 | Cholesterol metabolic process | IEA | biological_process |
| GO:0008289 | Lipid binding | TAS | molecular_function |
| GO:0034364 | High-density lipoprotein particle | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7226018844 | 0.2226742373 | 0.9999902473 | 0.9082610569 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0984980586 |
| GSE13712_SHEAR | Down | -0.4371499057 |
| GSE13712_STATIC | Down | -0.2658017287 |
| GSE19018 | Up | 0.2751056904 |
| GSE19899_A1 | Down | -0.4176891227 |
| GSE19899_A2 | Down | -0.3586940509 |
| PubMed_21979375_A1 | Down | -0.0447747530 |
| PubMed_21979375_A2 | Down | -0.0725390392 |
| GSE35957 | Up | 0.0079201662 |
| GSE36640 | Up | 0.0685311943 |
| GSE54402 | Down | -0.1729762518 |
| GSE9593 | Up | 0.3061507743 |
| GSE43922 | Up | 0.1053038943 |
| GSE24585 | Up | 0.1258070322 |
| GSE37065 | Down | -0.1037757815 |
| GSE28863_A1 | Up | 0.1858442318 |
| GSE28863_A2 | Up | 0.1646099743 |
| GSE28863_A3 | Down | -0.3299068599 |
| GSE28863_A4 | Down | -0.3081728091 |
| GSE48662 | Up | 0.3435591078 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025358 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025699 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT035959 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036841 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-548d-5p | MIMAT0004812 | MIRT037779 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039778 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042063 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042633 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-365a-3p | MIMAT0000710 | MIRT044029 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046605 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 8477745 | Vigilin is a cytoplasmic protein |
| 8477745 | Immunohistological studies on single cells showed that vigilin is accumulated in the cytoplasm |
| 8477745 | During in vitro maintenance of primary cell cultures, as well as of a growth-factor-dependent cell line, vigilin expression decreases and ceases in senescent cells |
| 8477745 | In contrast, vigilin is constitutively expressed in all other transformed cell lines of various origin studies so far |
| 8477745 | Vigilin expression can be induced in peripheral blood lymphocytes by mitogen stimulation |
| 8477745 | These observations suggest an involvement of vigilin in processes of cell activation |
| 8477745 | Immunoblot experiments demonstrating the presence of vigilin in a broad range of eukaryotes, indicate a high degree of evolutionary conservation |
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