HCSGD entry for SOX8

1. General information

Official gene symbolSOX8
Entrez ID30812
Gene full nameSRY (sex determining region Y)-box 8
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingISSmolecular_function
GO:0001649Osteoblast differentiationISSbiological_process
GO:0001701In utero embryonic developmentISSbiological_process
GO:0001755Neural crest cell migrationISSbiological_process
GO:0003677DNA bindingNASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIC IDAcellular_component
GO:0005737CytoplasmISScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007165Signal transductionISSbiological_process
GO:0007283SpermatogenesisISSbiological_process
GO:0007422Peripheral nervous system developmentISSbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0008584Male gonad developmentISSbiological_process
GO:0010817Regulation of hormone levelsISSbiological_process
GO:0014015Positive regulation of gliogenesisISSbiological_process
GO:0033690Positive regulation of osteoblast proliferationISSbiological_process
GO:0035914Skeletal muscle cell differentiationIEAbiological_process
GO:0043066Negative regulation of apoptotic processISSbiological_process
GO:0045165Cell fate commitmentISSbiological_process
GO:0045444Fat cell differentiationISSbiological_process
GO:0045662Negative regulation of myoblast differentiationISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046533Negative regulation of photoreceptor cell differentiationIEAbiological_process
GO:0048469Cell maturationIEAbiological_process
GO:0048484Enteric nervous system developmentISSbiological_process
GO:0048709Oligodendrocyte differentiationISSbiological_process
GO:0060009Sertoli cell developmentISSbiological_process
GO:0060018Astrocyte fate commitmentIEAbiological_process
GO:0060041Retina development in camera-type eyeISSbiological_process
GO:0060221Retinal rod cell differentiationISSbiological_process
GO:0060612Adipose tissue developmentISSbiological_process
GO:0061138Morphogenesis of a branching epitheliumISSbiological_process
GO:0072034Renal vesicle inductionISSbiological_process
GO:0072197Ureter morphogenesisISSbiological_process
GO:0072289Metanephric nephron tubule formationISSbiological_process
GO:0090184Positive regulation of kidney developmentISSbiological_process
GO:0090190Positive regulation of branching involved in ureteric bud morphogenesisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06828425970.93225372520.56122157351.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0428438227
GSE13712_SHEARDown-0.2042017856
GSE13712_STATICUp0.0201112287
GSE19018Down-0.3898268789
GSE19899_A1Up0.1816144595
GSE19899_A2Up0.6893509960
PubMed_21979375_A1Up1.1157882012
PubMed_21979375_A2Up1.2453038578
GSE35957Up0.0463877163
GSE36640Down-0.0042892152
GSE54402Up0.5594266086
GSE9593Down-0.0131990415
GSE43922Up0.1459353169
GSE24585Down-0.0137700590
GSE37065Up0.1240416134
GSE28863_A1Down-0.1821995189
GSE28863_A2Up0.0193028836
GSE28863_A3Up0.3614384877
GSE28863_A4Up0.0231669862
GSE48662Up0.1303159111

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-615-3pMIMAT0003283MIRT040234CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.