HCSGD entry for HLA-DQB1

1. General information

Official gene symbolHLA-DQB1
Entrez ID3119
Gene full namemajor histocompatibility complex, class II, DQ beta 1
Other gene symbolsCELIAC1 HLA-DQB IDDM1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0002344B cell affinity maturationIEAbiological_process
GO:0002381Immunoglobulin production involved in immunoglobulin mediated immune responseIDAbiological_process
GO:0002455Humoral immune response mediated by circulating immunoglobulinIDAbiological_process
GO:0002504Antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIIEAbiological_process
GO:0002579Positive regulation of antigen processing and presentationIEAbiological_process
GO:0002827Positive regulation of T-helper 1 type immune responseIEAbiological_process
GO:0005765Lysosomal membraneTAScellular_component
GO:0005769Early endosomeIEAcellular_component
GO:0005771Multivesicular bodyIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006955Immune responseIEA NASbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0010008Endosome membraneIEAcellular_component
GO:0012507ER to Golgi transport vesicle membraneTAScellular_component
GO:0015643Toxic substance bindingIEAmolecular_function
GO:0016020MembraneNAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IIIEA TASbiological_process
GO:0030658Transport vesicle membraneTAScellular_component
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0030669Clathrin-coated endocytic vesicle membraneTAScellular_component
GO:0031295T cell costimulationTASbiological_process
GO:0031625Ubiquitin protein ligase bindingIEAmolecular_function
GO:0032395MHC class II receptor activityNASmolecular_function
GO:0032588Trans-Golgi network membraneTAScellular_component
GO:0042605Peptide antigen bindingIEAmolecular_function
GO:0042613MHC class II protein complexIEAcellular_component
GO:0046635Positive regulation of alpha-beta T cell activationIEAbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0070491Repressing transcription factor bindingIEAmolecular_function
GO:0071346Cellular response to interferon-gammaIEAbiological_process
GO:0071556Integral component of lumenal side of endoplasmic reticulum membraneTAScellular_component
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85269474940.67104200830.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2366715044
GSE13712_SHEARUp0.0606676128
GSE13712_STATICUp0.0320582048
GSE19018Up0.0411512748
GSE19899_A1Up0.1131746411
GSE19899_A2Up0.0688332440
PubMed_21979375_A1Down-0.2115899328
PubMed_21979375_A2Up0.0456090101
GSE35957Down-0.0721182129
GSE36640Down-0.0554662252
GSE54402Up0.0124644274
GSE9593Down-0.2045172804
GSE43922Up0.0123298334
GSE24585Up0.2805658274
GSE37065Up0.0768568621
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.0558926934

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Insulin PorkDB00071 BTD00031 | BIOD00031

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.