HCSGD entry for HMBS
1. General information
| Official gene symbol | HMBS |
|---|---|
| Entrez ID | 3145 |
| Gene full name | hydroxymethylbilane synthase |
| Other gene symbols | PBG-D PBGD PORC UPS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004418 | Hydroxymethylbilane synthase activity | IDA IEA TAS | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006778 | Porphyrin-containing compound metabolic process | TAS | biological_process |
| GO:0006782 | Protoporphyrinogen IX biosynthetic process | IEA | biological_process |
| GO:0006783 | Heme biosynthetic process | IC TAS | biological_process |
| GO:0018160 | Peptidyl-pyrromethane cofactor linkage | IEA | biological_process |
| GO:0033014 | Tetrapyrrole biosynthetic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9507672999 | 0.0084670985 | 0.9999902473 | 0.1841600989 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1353281166 |
| GSE13712_SHEAR | Up | 0.7276757896 |
| GSE13712_STATIC | Up | 0.2034398755 |
| GSE19018 | Down | -0.2309136386 |
| GSE19899_A1 | Down | -0.8303568614 |
| GSE19899_A2 | Down | -0.4011830069 |
| PubMed_21979375_A1 | Up | 0.0203019078 |
| PubMed_21979375_A2 | Down | -0.7855505855 |
| GSE35957 | Down | -0.6159077020 |
| GSE36640 | Down | -0.7947575096 |
| GSE54402 | Up | 0.2946180321 |
| GSE9593 | Down | -0.9025483870 |
| GSE43922 | Down | -0.4818710021 |
| GSE24585 | Down | -0.6047870496 |
| GSE37065 | Down | -0.2577552872 |
| GSE28863_A1 | Down | -0.2202716578 |
| GSE28863_A2 | Down | -0.2382680171 |
| GSE28863_A3 | Down | -0.4669049638 |
| GSE28863_A4 | Up | 0.0643197980 |
| GSE48662 | Down | -0.4397041068 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-25-3p | MIMAT0000081 | MIRT050301 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
