HCSGD entry for FOXA2

1. General information

Official gene symbolFOXA2
Entrez ID3170
Gene full nameforkhead box A2
Other gene symbolsHNF3B TCF3B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIBAbiological_process
GO:0000432Positive regulation of transcription from RNA polymerase II promoter by glucoseISSbiological_process
GO:0000433Negative regulation of transcription from RNA polymerase II promoter by glucoseISSbiological_process
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001701In utero embryonic developmentIBAbiological_process
GO:0001705Ectoderm formationIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003690Double-stranded DNA bindingIBAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIBAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexIBAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIBAbiological_process
GO:0007389Pattern specification processIBAbiological_process
GO:0008134Transcription factor bindingIBAmolecular_function
GO:0008301DNA binding, bendingIBAmolecular_function
GO:0008344Adult locomotory behaviorIEAbiological_process
GO:0010719Negative regulation of epithelial to mesenchymal transitionIMPbiological_process
GO:0010817Regulation of hormone levelsIBAbiological_process
GO:0016568Chromatin modificationIEAbiological_process
GO:0019218Regulation of steroid metabolic processIEAbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0021533Cell differentiation in hindbrainIEAbiological_process
GO:0021904Dorsal/ventral neural tube patterningIEAbiological_process
GO:0023019Signal transduction involved in regulation of gene expressionIEAbiological_process
GO:0030193Regulation of blood coagulationIDAbiological_process
GO:0031018Endocrine pancreas developmentIDAbiological_process
GO:0032525Somite rostral/caudal axis specificationIEAbiological_process
GO:0033132Negative regulation of glucokinase activityISSbiological_process
GO:0040019Positive regulation of embryonic developmentISSbiological_process
GO:0042593Glucose homeostasisIBAbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIMPbiological_process
GO:0044212Transcription regulatory region DNA bindingIMPmolecular_function
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0045666Positive regulation of neuron differentiationIBAbiological_process
GO:0045880Positive regulation of smoothened signaling pathwayIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0045945Positive regulation of transcription from RNA polymerase III promoterIEAbiological_process
GO:0048468Cell developmentIEAbiological_process
GO:0048665Neuron fate specificationIBAbiological_process
GO:0060441Epithelial tube branching involved in lung morphogenesisIEAbiological_process
GO:0060487Lung epithelial cell differentiationIEAbiological_process
GO:0061178Regulation of insulin secretion involved in cellular response to glucose stimulusISSbiological_process
GO:0061448Connective tissue developmentIEAbiological_process
GO:0070741Response to interleukin-6TASbiological_process
GO:0071542Dopaminergic neuron differentiationIEAbiological_process
GO:0090009Primitive streak formationISSbiological_process
GO:2000049Positive regulation of cell-cell adhesion mediated by cadherinICbiological_process
GO:2000543Positive regulation of gastrulationISSbiological_process
GO:2000971Negative regulation of detection of glucoseISSbiological_process
GO:2000976Regulation of transcription from RNA polymerase II promoter involved in detection of glucoseISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48030077880.79115974320.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0014876465
GSE13712_SHEARDown-0.0127643290
GSE13712_STATICDown-0.0181037910
GSE19018Up0.0922607104
GSE19899_A1Up0.0862195583
GSE19899_A2Up0.1644601881
PubMed_21979375_A1Down-0.0505860073
PubMed_21979375_A2Down-0.0198300273
GSE35957Up0.0702954926
GSE36640Up0.0533489359
GSE54402Up0.0729676083
GSE9593Up0.1110527244
GSE43922Up0.1495420568
GSE24585Up0.0533158016
GSE37065Down-0.2479311525
GSE28863_A1Down-0.3408630174
GSE28863_A2Down-0.1569379877
GSE28863_A3Up0.5756313884
GSE28863_A4Up0.1396009316
GSE48662Down-0.0514069311

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017120MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23391216Foxa2 is one member of the Foxa subfamily of winged helix/forkhead box (Fox) transcription factors which has been found to play important roles in multiple stages of mammalian life, beginning with early development, continuing during organogenesis, and finally in metabolism and homeostasis in the adult
23391216To explore the involvement of Foxa2 and its epigenetic regulations in cellular senescence, we established the premature senescence model induced by hydrogen peroxide in comparison with replicative senescence
23391216The mRNA level of Foxa2 was downregulated in both replicative and premature senescent cells
23391216Moreover, we noted the alterations of histone modifications including decreased histone H3 acetylation, increased H4 (Lys-20) trimethylation at the Foxa2 CpG islands in the promoter in replicative or premature senescence, while decreased histone H3 (Lys-4) trimethylation across the transcription start regions in cellular senescence
23391216Taken together, epigenetic silencing of Foxa2 is associated with an increased DNA methylation level and histone H4 (Lys-20) trimethylation, decreased histone H3 acetylation and histone H3 (Lys-4) trimethylation, involved in cellular replicative or premature senescence
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