HCSGD entry for HP
1. General information
| Official gene symbol | HP |
|---|---|
| Entrez ID | 3240 |
| Gene full name | haptoglobin |
| Other gene symbols | BP HP2ALPHA2 HPA1S |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002376 | Immune system process | IEA | biological_process |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA NAS TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006952 | Defense response | TAS | biological_process |
| GO:0006953 | Acute-phase response | IEA | biological_process |
| GO:0010942 | Positive regulation of cell death | IDA | biological_process |
| GO:0016209 | Antioxidant activity | IEA | molecular_function |
| GO:0030492 | Hemoglobin binding | IDA IEA | molecular_function |
| GO:0031838 | Haptoglobin-hemoglobin complex | IDA | cellular_component |
| GO:0042542 | Response to hydrogen peroxide | IDA | biological_process |
| GO:0042742 | Defense response to bacterium | IEA | biological_process |
| GO:0051354 | Negative regulation of oxidoreductase activity | IDA | biological_process |
| GO:0071682 | Endocytic vesicle lumen | TAS | cellular_component |
| GO:2000296 | Negative regulation of hydrogen peroxide catabolic process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8821306143 | 0.1233412370 | 0.9999902473 | 0.6749406861 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0498932878 |
| GSE13712_SHEAR | Down | -0.0493177648 |
| GSE13712_STATIC | Down | -0.4558508928 |
| GSE19018 | Up | 0.0351046374 |
| GSE19899_A1 | Up | 0.0909479303 |
| GSE19899_A2 | Up | 0.3414529977 |
| PubMed_21979375_A1 | Down | -0.0760221619 |
| PubMed_21979375_A2 | Down | -0.2524868770 |
| GSE35957 | Up | 0.1030540610 |
| GSE36640 | Down | -0.0475082874 |
| GSE54402 | Up | 0.0038308677 |
| GSE9593 | Down | -2.9709557553 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.1935450161 |
| GSE28863_A2 | Down | -0.3083914224 |
| GSE28863_A3 | Up | 0.3073709156 |
| GSE28863_A4 | Up | 0.0463944123 |
| GSE48662 | Up | 0.0648872296 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27179971 | We identified the inflammation-related chaperone protein haptoglobin as the main component of the hyper-stable aggregates |
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