HCSGD entry for HSPA1A
1. General information
| Official gene symbol | HSPA1A |
|---|---|
| Entrez ID | 3303 |
| Gene full name | heat shock 70kDa protein 1A |
| Other gene symbols | HSP70-1 HSP70-1A HSP70I HSP72 HSPA1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001618 | Virus receptor activity | IEA | molecular_function |
| GO:0003725 | Double-stranded RNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA TAS | cellular_component |
| GO:0005739 | Mitochondrion | TAS | cellular_component |
| GO:0005783 | Endoplasmic reticulum | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006402 | MRNA catabolic process | IDA | biological_process |
| GO:0006986 | Response to unfolded protein | IDA | biological_process |
| GO:0008180 | COP9 signalosome | IDA | cellular_component |
| GO:0008285 | Negative regulation of cell proliferation | IMP | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0016234 | Inclusion body | IDA | cellular_component |
| GO:0016235 | Aggresome | IDA | cellular_component |
| GO:0016607 | Nuclear speck | IDA | cellular_component |
| GO:0030308 | Negative regulation of cell growth | IMP | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0042026 | Protein refolding | IDA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IMP TAS | biological_process |
| GO:0044183 | Protein binding involved in protein folding | IDA | molecular_function |
| GO:0045648 | Positive regulation of erythrocyte differentiation | IMP | biological_process |
| GO:0047485 | Protein N-terminus binding | IPI | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0051082 | Unfolded protein binding | TAS | molecular_function |
| GO:0090084 | Negative regulation of inclusion body assembly | IDA | biological_process |
| GO:2001240 | Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9070388929 | 0.6456723985 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.3975566218 |
| GSE28863_A2 | Up | 0.2083945916 |
| GSE28863_A3 | Up | 0.0403906557 |
| GSE28863_A4 | Down | -0.2643506546 |
| GSE48662 | Down | -0.2543995264 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000866 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001456 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001456 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018150 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-146a-5p | MIMAT0000449 | MIRT021244 | Microarray | Functional MTI (Weak) | 18057241 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025302 | Proteomics | Functional MTI (Weak) | 21566225 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | 1 | hsa-miR-1 | 17715156 | |||
| hsa-miR-15a-5p | MIMAT0000068 | NA | hsa-miR-15a | 18362358 | |||
| hsa-miR-16-5p | MIMAT0000069 | NA | hsa-miR-16 | 18362358 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21297664 | Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis |
| 21297664 | The major heat shock protein Hsp72 is expressed at elevated levels in many human cancers and its expression correlates with tumor progression |
| 21297664 | Here, we investigated the role of Hsp72 in Her2 oncogene-induced neoplastic transformation and tumorigenesis |
| 21297664 | The anti-tumorigenic effects of Hsp72 downregulation were associated with cellular senescence because of accumulation of p21 and depletion of survivin |
| 21297664 | Knockout (KO) of Hsp72 almost completely suppressed tumorigenesis in the MMTVneu breast cancer mouse model |
| 21297664 | In young Hsp72 KO mice, expression of Her2 instead of mammary tissue hyperplasia led to suppression of duct development and blocked alveolar budding |
| 21297664 | Therefore, Hsp72 has an essential role in Her2-induced tumorigenesis by regulating oncogene-induced senescence pathways |
| 17332370 | High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathways |
| 17332370 | The major heat shock protein Hsp72 is constitutively expressed in many tumor cell lines and biopsies, and its expression correlates with poor prognosis in several types of cancer |
| 17332370 | Hsp72 was suggested to play an important role in neoplastic transformation and tumor development |
| 17332370 | We addressed the role of Hsp72 in cancer cells by investigating the consequences of specific depletion of Hsp72 using small interfering RNA |
| 17332370 | Down-regulation of Hsp72 in certain cancer lines triggered cell senescence associated with activation and stabilization of p53 and induction of the cell cycle inhibitor p21 |
| 17332370 | Effects of Hsp72 depletion on senescence and p53 did not result from a proteotoxic stress, DNA instability, or activation of ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related pathways |
| 17332370 | Instead, depletion of Hsp72 reduced stability and activity of the p53 inhibitor Hdm2 |
| 17332370 | Therefore, Hsp72 provides a selective advantage to cancer cells by suppressing default senescence via p53-dependent and p53-independent pathways |
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