HCSGD entry for HSPA2
1. General information
| Official gene symbol | HSPA2 |
|---|---|
| Entrez ID | 3306 |
| Gene full name | heat shock 70kDa protein 2 |
| Other gene symbols | HSP70-2 HSP70-3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000795 | Synaptonemal complex | IEA | cellular_component |
| GO:0001673 | Male germ cell nucleus | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006986 | Response to unfolded protein | TAS | biological_process |
| GO:0007140 | Male meiosis | TAS | biological_process |
| GO:0007141 | Male meiosis I | IEA | biological_process |
| GO:0007286 | Spermatid development | IEA | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0031662 | Positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle | IEA | biological_process |
| GO:0036128 | CatSper complex | ISS | cellular_component |
| GO:0051082 | Unfolded protein binding | TAS | molecular_function |
| GO:0051861 | Glycolipid binding | IEA | molecular_function |
| GO:0070194 | Synaptonemal complex disassembly | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9650904753 | 0.0000110330 | 0.9999902473 | 0.0069833333 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -2.8769446076 |
| GSE13712_SHEAR | Down | -2.7310495750 |
| GSE13712_STATIC | Down | -2.4472202049 |
| GSE19018 | Down | -1.3513563029 |
| GSE19899_A1 | Down | -3.9816462485 |
| GSE19899_A2 | Down | -3.9831165504 |
| PubMed_21979375_A1 | Down | -2.2521826158 |
| PubMed_21979375_A2 | Down | -5.0860469071 |
| GSE35957 | Down | -1.8466539251 |
| GSE36640 | Down | -0.6235929790 |
| GSE54402 | Down | -1.9074175432 |
| GSE9593 | Down | -0.7134461345 |
| GSE43922 | Down | -1.9983883817 |
| GSE24585 | Up | 1.5614315471 |
| GSE37065 | Up | 0.0911527933 |
| GSE28863_A1 | Down | -0.1706380983 |
| GSE28863_A2 | Up | 0.0674437057 |
| GSE28863_A3 | Up | 0.0278649091 |
| GSE28863_A4 | Down | -0.0867552570 |
| GSE48662 | Down | -0.1812716629 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024730 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026895 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036912 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
