HCSGD entry for HSPA8

1. General information

Official gene symbolHSPA8
Entrez ID3312
Gene full nameheat shock 70kDa protein 8
Other gene symbolsHSC54 HSC70 HSC71 HSP71 HSP73 HSPA10 LAP1 NIP71
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000974Prp19 complexIDAcellular_component
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005622IntracellularNAScellular_component
GO:0005634NucleusIDAcellular_component
GO:0005681Spliceosomal complexIEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006200ATP catabolic processNASbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006397MRNA processingIEAbiological_process
GO:0006457Protein foldingNASbiological_process
GO:0006892Post-Golgi vesicle-mediated transportTASbiological_process
GO:0006986Response to unfolded proteinNASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007269Neurotransmitter secretionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008380RNA splicingIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0030529Ribonucleoprotein complexIDAcellular_component
GO:0042470MelanosomeIEAcellular_component
GO:0042623ATPase activity, coupledIEA NASmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0051082Unfolded protein bindingIEAmolecular_function
GO:0051085Chaperone mediated protein folding requiring cofactorIEAbiological_process
GO:0051726Regulation of cell cycleIEAbiological_process
GO:0061202Clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneTAScellular_component
GO:0070062Extracellular vesicular exosomeIDA IEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99887476920.04038918730.99999024730.3792664288

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.2161691016

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diolDB07045 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-877-5pMIMAT0004949MIRT037227CLASHFunctional MTI (Weak)23622248
hsa-miR-151a-5pMIMAT0004697MIRT038193CLASHFunctional MTI (Weak)23622248
hsa-miR-130b-5pMIMAT0004680MIRT038316CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039668CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042836CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044798CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045436CLASHFunctional MTI (Weak)23622248
hsa-miR-15b-5pMIMAT0000417MIRT046453CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047545CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049282CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050082CLASHFunctional MTI (Weak)23622248
hsa-miR-25-3pMIMAT0000081MIRT050343CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051117CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052021CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27091568Western blotting and protein labeling experiments demonstrated that neither mild heat shock nor exogenous HSP70 administration resulted in significant endogenous HSP70 induction in young and aged MSCs, whereas mild heat shock increased HSC70 levels in aged MSCs
26640786RESULTS: Comparison of protein pattern of senescent and young HPMC revealed 29 differentially abundant protein spots, 11 of which were identified to be actin (cytoplasmic 1 and 2), cytokeratin-7, cofilin-2, transgelin-2, Hsp60, Hsc70, proteasome beta-subunits (type-2 and type-3), nucleoside diphosphate kinase A, and cytosolic 5'(3')-deoxyribonucleotidase
23551866Expression of adrenomedullin (ADM), heat shock 70 kDa protein 8 (HSPA8) and prostaglandin E synthase (PGES) in OPEC was measured by quantitative polymerase chain reaction
23551866The expression of ADM and HSPA8 was decreased significantly in OPEC cells from Passage 57, particularly in the later subculture group
23551866These effects on HSPA8, but not ADM, expression in OPEC were further altered after coculture with spermatozoa for 24 h
23551866We also demonstrated that spermatozoa-oviduct coculture for 12 and 24 h resulted in significantly higher expression of ADM, HSPA8 and PGES in OPEC
19009367Identification of Hsc70 as target for AGE modification in senescent human fibroblasts
17162659T antigen and the T' proteins share N-terminal amino acid sequences that include the L x CxE and J domains, motifs in SV40 T antigen known to mediate binding to the retinoblastoma (Rb) proteins and Hsc70, respectively
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