HCSGD entry for HSPA9
1. General information
| Official gene symbol | HSPA9 |
|---|---|
| Entrez ID | 3313 |
| Gene full name | heat shock 70kDa protein 9 (mortalin) |
| Other gene symbols | CSA GRP-75 GRP75 HSPA9B MOT MOT2 MTHSP75 PBP74 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005739 | Mitochondrion | IDA IEA TAS | cellular_component |
| GO:0006457 | Protein folding | IEA | biological_process |
| GO:0006611 | Protein export from nucleus | IEA | biological_process |
| GO:0006626 | Protein targeting to mitochondrion | TAS | biological_process |
| GO:0019899 | Enzyme binding | IEA | molecular_function |
| GO:0042645 | Mitochondrial nucleoid | IDA | cellular_component |
| GO:0043066 | Negative regulation of apoptotic process | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0051082 | Unfolded protein binding | TAS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0949466282 | 0.9090842027 | 0.6451888487 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3207612942 |
| GSE13712_SHEAR | Up | 0.4606026394 |
| GSE13712_STATIC | Up | 0.4265491292 |
| GSE19018 | Down | -0.3193677626 |
| GSE19899_A1 | Up | 0.3966938627 |
| GSE19899_A2 | Up | 0.1224735106 |
| PubMed_21979375_A1 | Up | 0.4238472664 |
| PubMed_21979375_A2 | Up | 0.0940289007 |
| GSE35957 | Down | -0.1442817300 |
| GSE36640 | Down | -0.2149852833 |
| GSE54402 | Up | 0.3058427549 |
| GSE9593 | Up | 0.1863162508 |
| GSE43922 | Up | 0.0420608137 |
| GSE24585 | Up | 0.0130109013 |
| GSE37065 | Up | 0.0079751435 |
| GSE28863_A1 | Up | 0.0388538448 |
| GSE28863_A2 | Up | 0.2850234293 |
| GSE28863_A3 | Up | 0.1507241030 |
| GSE28863_A4 | Down | -0.2811967169 |
| GSE48662 | Up | 0.0188964020 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031608 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036458 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039907 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042742 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042957 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044460 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26161649 | Grp75 binds with an affinity of approximately 3-7 nM with reticulocalbin as well as with calumenin |
| 25645922 | Mortalin/mtHsp70/Grp75 (mot-2), a heat shock protein 70 family member, is an essential chaperone, enriched in cancers, and has been shown to possess pro-proliferative and anti-apoptosis functions |
| 25645922 | These factors may mediate the transformation of longevity/pro-proliferative function of mot-2 to the premature aging/anti-proliferative effect of mutants, and hence may have significance in cellular aging, Parkinson disease pathology, and prognosis |
| 17460192 | Mortalin (mtHSP70/GRP75) is a heat uninducible member of hsp70 family of proteins |
| 12646231 | Mortalin (mot-2/GRP75/PBP74/mthsp70) is a member of the hsp70 family of proteins and is differentially distributed in normal and immortal cells |
| 12646231 | To elucidate its functional aspects, a yeast interactive screen for mortalin (mot-2) binding proteins was performed |
| 12646231 | An overexpression of mot-2 resulted in reduced level of Ras and phosphorylated ERK2 |
| 12646231 | These were rescued by co-expression of MPD from an exogenous promoter demonstrating a functional link between mot-2, MPD, and Ras |
| 12646231 | Assigning mot-2 upstream of p21(Ras) offers an important mechanism for influence over cell proliferation |
| 11187902 | Human mortalin (HSPA9): a candidate for the myeloid leukemia tumor suppressor gene on 5q31 |
| 11187902 | Human mortalin (HSPA9) was originally identified by its close homology to murine mortalins, which play important roles in cellular senescence |
| 11187902 | The two murine genes, mot-1 and mot-2, differ in only two amino acid residues, but have opposite functions in cellular immortalization |
| 11187902 | HSPA9 was recently localized to chromosome 5, band q31, a region that is frequently deleted in myeloid leukemias and myelodysplasia (MDS), making it a candidate tumor suppressor gene, which is consistent with the biological function of its murine homologue |
| 7693662 | Here, we report that the cytosolic (mot-1) and the perinuclear (mot-2) forms of mortalin cDNA cloned from mortal and immortal cells, respectively, differ by only two bases in the open reading frame, resulting in two amino acid changes |
| 7693662 | However, the perinuclear form expressed by mot-2 cDNA (isolate from NIH 3T3 cells) did not yield an equivalent effect |
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