HCSGD entry for HTR2B

1. General information

Official gene symbolHTR2B
Entrez ID3357
Gene full name5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
Other gene symbols5-HT(2B) 5-HT2B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001755Neural crest cell migrationISSbiological_process
GO:0001819Positive regulation of cytokine productionIDAbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIMPbiological_process
GO:0001965G-protein alpha-subunit bindingIMPmolecular_function
GO:0002031G-protein coupled receptor internalizationIEAbiological_process
GO:0003007Heart morphogenesisISSbiological_process
GO:0003300Cardiac muscle hypertrophyISSbiological_process
GO:0004993Serotonin receptor activityIDAmolecular_function
GO:0005099Ras GTPase activator activityISSmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0006182CGMP biosynthetic processIDAbiological_process
GO:0006874Cellular calcium ion homeostasisIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIMPbiological_process
GO:0007202Activation of phospholipase C activityIDAbiological_process
GO:0007205Protein kinase C-activating G-protein coupled receptor signaling pathwayISSbiological_process
GO:0007210Serotonin receptor signaling pathwayIMPbiological_process
GO:0007610BehaviorIEAbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:0008284Positive regulation of cell proliferationIDA IMPbiological_process
GO:0010507Negative regulation of autophagyIMPbiological_process
GO:0010513Positive regulation of phosphatidylinositol biosynthetic processIDAbiological_process
GO:0014033Neural crest cell differentiationISSbiological_process
GO:0014065Phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0014827Intestine smooth muscle contractionIMPbiological_process
GO:0016310PhosphorylationIMPbiological_process
GO:0019722Calcium-mediated signalingIMPbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0042310VasoconstrictionIMPbiological_process
GO:0042493Response to drugIDAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043066Negative regulation of apoptotic processISSbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEPbiological_process
GO:0043406Positive regulation of MAP kinase activityIDAbiological_process
GO:0045202SynapseIEAcellular_component
GO:0048598Embryonic morphogenesisISSbiological_process
GO:0050715Positive regulation of cytokine secretionISSbiological_process
GO:0050795Regulation of behaviorIMPbiological_process
GO:0051000Positive regulation of nitric-oxide synthase activityIDAbiological_process
GO:0051209Release of sequestered calcium ion into cytosolIDA IMPbiological_process
GO:0051378Serotonin bindingIDAmolecular_function
GO:0051781Positive regulation of cell divisionISSbiological_process
GO:0060548Negative regulation of cell deathIMPbiological_process
GO:0070371ERK1 and ERK2 cascadeIMPbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0070528Protein kinase C signalingIMPbiological_process
GO:0071502Cellular response to temperature stimulusISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.81735171160.00132121120.99999024730.0702537374

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3321214886
GSE13712_SHEARDown-4.7259425216
GSE13712_STATICDown-2.1279953662
GSE19018Down-0.5944525451
GSE19899_A1Down-0.0815956959
GSE19899_A2Down-2.4960310557
PubMed_21979375_A1Down-0.9767990839
PubMed_21979375_A2Down-0.9344395400
GSE35957Up0.5955731741
GSE36640Down-0.7809270397
GSE54402Up0.3676365540
GSE9593Up0.6176432194
GSE43922Down-2.9252753100
GSE24585Up0.0517249489
GSE37065Down-0.3835589624
GSE28863_A1Down-0.0971882773
GSE28863_A2Up0.2969165636
GSE28863_A3Down-0.2751163237
GSE28863_A4Down-0.2345654920
GSE48662Down-0.0282274206

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

EletriptanDB00216 APRD00945
RopiniroleDB00268 APRD00302
OlanzapineDB00334 APRD00138
MirtazapineDB00370 APRD00685
TriflupromazineDB00508 APRD00465
AmoxapineDB00543 APRD00142
FenfluramineDB00574 APRD00319
LisurideDB00589 APRD00636
MinaprineDB00805 APRD00735
TegaserodDB01079 APRD00096
DoxepinDB01142 APRD00398
PergolideDB01186 APRD00663
ChlorprothixeneDB01239 APRD00718
3,4-MethylenedioxymethamphetamineDB01454 -
OPC-28326DB05461 -
Epicept NP-1DB05492 DB08290
MianserinDB06148 -
AsenapineDB06216 -
KetamineDB01221 APRD00493
EsmirtazapineDB06678 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

6967355For individual mast cells, relationships between their dry mass and their content of heparin and 5-hydroxytryptamine (5-HT) were studied
6967355The capacity of the mast cells to accumulate 5-HT after a single injection of its precursor, 5-hydroxytryptophan, was used as a functional test
6967355In relation to the cell weight, the induced increase of 5-HT was greater for lighter than for heavier mast cells
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