HCSGD entry for IGFBP2
1. General information
| Official gene symbol | IGFBP2 |
|---|---|
| Entrez ID | 3485 |
| Gene full name | insulin-like growth factor binding protein 2, 36kDa |
| Other gene symbols | IBP2 IGF-BP53 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001558 | Regulation of cell growth | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005520 | Insulin-like growth factor binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA ISS TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA IEA | cellular_component |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0007565 | Female pregnancy | IEA | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0007584 | Response to nutrient | IEA | biological_process |
| GO:0009612 | Response to mechanical stimulus | IEA | biological_process |
| GO:0010226 | Response to lithium ion | IEA | biological_process |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0031410 | Cytoplasmic vesicle | IEA | cellular_component |
| GO:0031994 | Insulin-like growth factor I binding | IDA IEA | molecular_function |
| GO:0031995 | Insulin-like growth factor II binding | IEA ISS | molecular_function |
| GO:0032355 | Response to estradiol | IEA | biological_process |
| GO:0032526 | Response to retinoic acid | IEA | biological_process |
| GO:0032870 | Cellular response to hormone stimulus | IEA | biological_process |
| GO:0042104 | Positive regulation of activated T cell proliferation | IDA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043567 | Regulation of insulin-like growth factor receptor signaling pathway | IC ISS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0347913339 | 0.0063446830 | 0.4261199164 | 0.1620256062 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2949240306 |
| GSE13712_SHEAR | Up | 0.0538168668 |
| GSE13712_STATIC | Down | -0.3350977970 |
| GSE19018 | Down | -0.5527794160 |
| GSE19899_A1 | Down | -0.5373668461 |
| GSE19899_A2 | Up | 0.2362772214 |
| PubMed_21979375_A1 | Down | -0.3037461922 |
| PubMed_21979375_A2 | Down | -3.9911727757 |
| GSE35957 | Down | -0.9220832397 |
| GSE36640 | Down | -0.1428983177 |
| GSE54402 | Down | -1.2448798012 |
| GSE9593 | Up | 0.6104360866 |
| GSE43922 | Down | -0.4819766897 |
| GSE24585 | Down | -0.2955156965 |
| GSE37065 | Down | -0.8438600983 |
| GSE28863_A1 | Down | -0.4515862187 |
| GSE28863_A2 | Up | 1.0365864023 |
| GSE28863_A3 | Up | 1.0762234958 |
| GSE28863_A4 | Up | 0.0825633425 |
| GSE48662 | Up | 2.7241110019 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-126-3p | MIMAT0000445 | MIRT006543 | ELISA//Flow//Immunohistochemistry//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 22170610 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017411 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22384354 | A slight but significant positive correlation between expression levels and telomere length was observed for many of the candidate genes, but Ibp2 was a notable exception, showing instead a negative correlation |
| 11381070 | PURPOSE: Previous studies have shown that insulin-like growth factor-binding protein (IGFBP)-2 is markedly upregulated in senescent RPE cells in vitro, and might therefore be a marker of senescent cells in vivo |
| 11381070 | This study was conducted to determine whether IGFBP-2 expression in human RPE cells from the macula and periphery varies with age in vivo |
| 11381070 | METHODS: Paraformaldehyde (4%)-fixed and optimal cutting temperature (OCT) compound-embedded human eyes from 17 patients were cryosectioned and subjected to high-sensitivity digoxigenin (DIG)-labeled cRNA in situ hybridization to determine the expression of IGFBP-2 |
| 11381070 | Complementary immunohistochemistry experiments using a polyclonal anti-IGFBP-2 antibody were performed to confirm IGFBP-2 protein expression |
| 11381070 | The total numbers of RPE cells and IGFBP-2 mRNA expression-positive RPE cells were counted for each section, and the ratio of labeled RPE cells to total RPE cells counted was calculated for both macular and peripheral regions of each donor |
| 11381070 | RESULTS: IGFBP-2 mRNA expression was detected in the ganglion cell layer, inner and outer nuclear layers, and inner segments of photoreceptor cells in all 17 eyes |
| 11381070 | In 16 of 17 eyes, IGFBP-2 mRNA expression was detected in the RPE |
| 11381070 | Immunohistochemistry studies for IGFBP-2 confirmed the expression pattern found by in situ hybridization |
| 11381070 | CONCLUSIONS: There is a topographical and age-related change in IGFBP-2 expression in RPE cells from human donor eyes |
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