HCSGD entry for IL6ST

1. General information

Official gene symbolIL6ST
Entrez ID3572
Gene full nameinterleukin 6 signal transducer (gp130, oncostatin M receptor)
Other gene symbolsCD130 CDW130 GP130 IL-6RB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002675Positive regulation of acute inflammatory responseICbiological_process
GO:0002821Positive regulation of adaptive immune responseICbiological_process
GO:0004897Ciliary neurotrophic factor receptor activityIDAmolecular_function
GO:0004915Interleukin-6 receptor activityIDA IGImolecular_function
GO:0004921Interleukin-11 receptor activityIEAmolecular_function
GO:0004923Leukemia inhibitory factor receptor activityIGImolecular_function
GO:0004924Oncostatin-M receptor activityIDAmolecular_function
GO:0005127Ciliary neurotrophic factor receptor bindingIPImolecular_function
GO:0005138Interleukin-6 receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005896Interleukin-6 receptor complexIDAcellular_component
GO:0005900Oncostatin-M receptor complexIDAcellular_component
GO:0005977Glycogen metabolic processIEAbiological_process
GO:0008284Positive regulation of cell proliferationIDA IGIbiological_process
GO:0008593Regulation of Notch signaling pathwayIEAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0010575Positive regulation vascular endothelial growth factor productionTASbiological_process
GO:0010613Positive regulation of cardiac muscle hypertrophyTASbiological_process
GO:0016032Viral processIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayIDAbiological_process
GO:0019838Growth factor bindingIPImolecular_function
GO:0019970Interleukin-11 bindingIEAmolecular_function
GO:0019981Interleukin-6 bindingIPImolecular_function
GO:0030425DendriteIEAcellular_component
GO:0034097Response to cytokineIDAbiological_process
GO:0038165Oncostatin-M-mediated signaling pathwayIMPbiological_process
GO:0042102Positive regulation of T cell proliferationIMPbiological_process
GO:0042511Positive regulation of tyrosine phosphorylation of Stat1 proteinIMPbiological_process
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinIMPbiological_process
GO:0042803Protein homodimerization activityTASmolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0045509Interleukin-27 receptor activityICmolecular_function
GO:0045669Positive regulation of osteoblast differentiationIMPbiological_process
GO:0048711Positive regulation of astrocyte differentiationIEAbiological_process
GO:0048861Leukemia inhibitory factor signaling pathwayIGIbiological_process
GO:0070102Interleukin-6-mediated signaling pathwayIMPbiological_process
GO:0070104Negative regulation of interleukin-6-mediated signaling pathwayIDAbiological_process
GO:0070106Interleukin-27-mediated signaling pathwayIMPbiological_process
GO:0070110Ciliary neurotrophic factor receptor complexIDAcellular_component
GO:0070120Ciliary neurotrophic factor-mediated signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04461794380.79589487100.46962026381.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4174809994
GSE13712_SHEARDown-0.1013321518
GSE13712_STATICDown-0.2984784994
GSE19018Down-0.3446033483
GSE19899_A1Down-0.2257208007
GSE19899_A2Down-0.3625999873
PubMed_21979375_A1Down-0.2383615772
PubMed_21979375_A2Up0.4893546056
GSE35957Up0.6386761601
GSE36640Up0.3064405328
GSE54402Down-0.0292558544
GSE9593Up0.6000007532
GSE43922Up0.2496738261
GSE24585Up0.6790343570
GSE37065Up0.1153753044
GSE28863_A1Up0.0258731064
GSE28863_A2Down-0.0238946171
GSE28863_A3Down-0.0023781677
GSE28863_A4Down-0.0127745290
GSE48662Up0.9551017656

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-590-3pMIMAT0004801MIRT016213SequencingFunctional MTI (Weak)20371350
hsa-miR-335-5pMIMAT0000765MIRT017169MicroarrayFunctional MTI (Weak)18185580
hsa-miR-215-5pMIMAT0000272MIRT024434MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026283MicroarrayFunctional MTI (Weak)19074876
hsa-miR-615-3pMIMAT0003283MIRT040397CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.