HCSGD entry for IL12A

1. General information

Official gene symbolIL12A
Entrez ID3592
Gene full nameinterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
Other gene symbolsCLMF IL-12A NFSK NKSF1 P35
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001916Positive regulation of T cell mediated cytotoxicityIDAbiological_process
GO:0002860Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetIDAbiological_process
GO:0005125Cytokine activityIDA TASmolecular_function
GO:0005143Interleukin-12 receptor bindingIEA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006955Immune responseIEA TASbiological_process
GO:0007050Cell cycle arrestIDAbiological_process
GO:0008083Growth factor activityIDA IEA NASmolecular_function
GO:0009615Response to virusIEPbiological_process
GO:0010224Response to UV-BIDAbiological_process
GO:0016477Cell migrationIDAbiological_process
GO:0032496Response to lipopolysaccharideIDAbiological_process
GO:0032700Negative regulation of interleukin-17 productionIDAbiological_process
GO:0032729Positive regulation of interferon-gamma productionIDAbiological_process
GO:0032816Positive regulation of natural killer cell activationIDAbiological_process
GO:0034393Positive regulation of smooth muscle cell apoptotic processIDAbiological_process
GO:0042102Positive regulation of T cell proliferationIEAbiological_process
GO:0042163Interleukin-12 beta subunit bindingIEAmolecular_function
GO:0042520Positive regulation of tyrosine phosphorylation of Stat4 proteinIDAbiological_process
GO:0042832Defense response to protozoanIEAbiological_process
GO:0043514Interleukin-12 complexIDA NAScellular_component
GO:0045513Interleukin-27 bindingIPImolecular_function
GO:0045582Positive regulation of T cell differentiationIEAbiological_process
GO:0045785Positive regulation of cell adhesionIDAbiological_process
GO:0045954Positive regulation of natural killer cell mediated cytotoxicityIDAbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0048662Negative regulation of smooth muscle cell proliferationIDAbiological_process
GO:0050671Positive regulation of lymphocyte proliferationIDAbiological_process
GO:0050830Defense response to Gram-positive bacteriumIEPbiological_process
GO:0051135Positive regulation of NK T cell activationIDAbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01392600590.31887402450.29370439651.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0092616993
GSE13712_SHEARUp0.0276227699
GSE13712_STATICDown-0.7745405333
GSE19018Down-0.4915100086
GSE19899_A1Up0.1276211320
GSE19899_A2Up2.2440340437
PubMed_21979375_A1Up0.9151398694
PubMed_21979375_A2Up1.1421564053
GSE35957Down-0.2217333562
GSE36640Up2.5667758563
GSE54402Up0.4014155006
GSE9593Up0.4949317878
GSE43922Up0.9259565881
GSE24585Down-1.3632641609
GSE37065Up0.0888466037
GSE28863_A1Down-0.1629449133
GSE28863_A2Up0.2597185667
GSE28863_A3Up0.0417686550
GSE28863_A4Up0.0054464050
GSE48662Down-0.0736670655

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030009MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.