HCSGD entry for IL12RB1

1. General information

Official gene symbolIL12RB1
Entrez ID3594
Gene full nameinterleukin 12 receptor, beta 1
Other gene symbolsCD212 IL-12R-BETA1 IL12RB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001916Positive regulation of T cell mediated cytotoxicityISSbiological_process
GO:0002230Positive regulation of defense response to virus by hostIDA ISSbiological_process
GO:0002827Positive regulation of T-helper 1 type immune responseIDA ISSbiological_process
GO:0004896Cytokine receptor activityTASmolecular_function
GO:0005143Interleukin-12 receptor bindingIPImolecular_function
GO:0007165Signal transductionICbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0016517Interleukin-12 receptor activityIDAmolecular_function
GO:0018108Peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019955Cytokine bindingIEAmolecular_function
GO:0032729Positive regulation of interferon-gamma productionIDA IMPbiological_process
GO:0035722Interleukin-12-mediated signaling pathwayIDAbiological_process
GO:0038155Interleukin-23-mediated signaling pathwayIDAbiological_process
GO:0042019Interleukin-23 bindingIPImolecular_function
GO:0042020Interleukin-23 receptor activityIDAmolecular_function
GO:0042022Interleukin-12 receptor complexIDAcellular_component
GO:0042104Positive regulation of activated T cell proliferationIDAbiological_process
GO:0043382Positive regulation of memory T cell differentiationISSbiological_process
GO:0071346Cellular response to interferon-gammaIDAbiological_process
GO:0072536Interleukin-23 receptor complexIDAcellular_component
GO:2000318Positive regulation of T-helper 17 type immune responseISSbiological_process
GO:2000330Positive regulation of T-helper 17 cell lineage commitmentISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.44982349450.83653713000.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0708716295
GSE13712_SHEARUp0.0777244187
GSE13712_STATICDown-0.0703620950
GSE19018Up0.0301299013
GSE19899_A1Up0.0055080542
GSE19899_A2Up0.0601843975
PubMed_21979375_A1Up0.0539673952
PubMed_21979375_A2Down-0.0528761451
GSE35957Up0.0975341165
GSE36640Up0.1912005938
GSE54402Up0.0404929352
GSE9593Up0.0632158736
GSE43922Up0.0517346171
GSE24585Down-0.0293470271
GSE37065Up0.0331687798
GSE28863_A1Down-0.1939148189
GSE28863_A2Down-0.1354382259
GSE28863_A3Up0.2842895800
GSE28863_A4Up0.3668077152
GSE48662Up0.1792600117

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.