HCSGD entry for IL18

1. General information

Official gene symbolIL18
Entrez ID3606
Gene full nameinterleukin 18 (interferon-gamma-inducing factor)
Other gene symbolsIGIF IL-18 IL-1g IL1F4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeIMPbiological_process
GO:0001525AngiogenesisIDAbiological_process
GO:0005125Cytokine activityTASmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006954Inflammatory responseIDAbiological_process
GO:0006955Immune responseTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0030101Natural killer cell activationIEAbiological_process
GO:0030155Regulation of cell adhesionIDAbiological_process
GO:0030431SleepISSbiological_process
GO:0031663Lipopolysaccharide-mediated signaling pathwayIDAbiological_process
GO:0032725Positive regulation of granulocyte macrophage colony-stimulating factor productionIDAbiological_process
GO:0032729Positive regulation of interferon-gamma productionIDAbiological_process
GO:0032740Positive regulation of interleukin-17 productionIDAbiological_process
GO:0032819Positive regulation of natural killer cell proliferationIDAbiological_process
GO:0034105Positive regulation of tissue remodelingICbiological_process
GO:0042033Chemokine biosynthetic processTASbiological_process
GO:0042088T-helper 1 type immune responseIDAbiological_process
GO:0042092Type 2 immune responseTASbiological_process
GO:0042094Interleukin-2 biosynthetic processTASbiological_process
GO:0042095Interferon-gamma biosynthetic processTASbiological_process
GO:0042104Positive regulation of activated T cell proliferationIDAbiological_process
GO:0042231Interleukin-13 biosynthetic processTASbiological_process
GO:0042253Granulocyte macrophage colony-stimulating factor biosynthetic processTASbiological_process
GO:0042346Positive regulation of NF-kappaB import into nucleusIEAbiological_process
GO:0050729Positive regulation of inflammatory responseICbiological_process
GO:0051142Positive regulation of NK T cell proliferationIDAbiological_process
GO:0071407Cellular response to organic cyclic compoundIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13511624180.21929167960.74333895970.9012262295

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0006053736
GSE13712_SHEARUp1.7573961393
GSE13712_STATICUp1.9347343411
GSE19018Down-0.1816545568
GSE19899_A1Down-0.2220545473
GSE19899_A2Down-0.5850992317
PubMed_21979375_A1Down-0.1345155371
PubMed_21979375_A2Down-0.4651576534
GSE35957Up0.3404080927
GSE36640Up0.0159048852
GSE54402Down-0.2754416166
GSE9593Up0.1590279538
GSE43922Down-0.6429513948
GSE24585Up0.4737090928
GSE37065Down-0.0185182972
GSE28863_A1Down-0.0509441320
GSE28863_A2Down-0.1546901512
GSE28863_A3Up0.2119268538
GSE28863_A4Down-0.0612316958
GSE48662Up0.1707827225

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-346MIMAT0000773MIRT004304qRT-PCR//Luciferase reporter assay//Western blot//Northern blotNon-Functional MTI19342689
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27547293Compared to their normobilirubinemic siblings, aged hyperbilirubinemic Gunn rats showed significantly smaller amounts of visceral fat, better glucose tolerance, and decreased serum levels of proinflammatory cytokines TNFalpha, IL-1beta, and IL-18
25989853However, pathological stabilization of the actin cytoskeleton increased LPS-induced release of IL-1beta and IL-18, which belong to an unconventional secretory pathway
23864729Activation of the AIM2 inflammasome cleaves pro-interleukin (IL)-1beta and pro-IL-18 and promotes the secretion of IL-1beta and IL-18 proinflammatory cytokines
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