HCSGD entry for INS

1. General information

Official gene symbolINS
Entrez ID3630
Gene full nameinsulin
Other gene symbolsIDDM2 ILPR IRDN MODY10
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeIDAbiological_process
GO:0002020Protease bindingIPImolecular_function
GO:0002674Negative regulation of acute inflammatory responseIDAbiological_process
GO:0005158Insulin receptor bindingIDA IPImolecular_function
GO:0005159Insulin-like growth factor receptor bindingIPImolecular_function
GO:0005179Hormone activityIC IEA IMP NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIC IEA TAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0006006Glucose metabolic processIEAbiological_process
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0006521Regulation of cellular amino acid metabolic processIMPbiological_process
GO:0006953Acute-phase responseIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007267Cell-cell signalingICbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0015758Glucose transportIDAbiological_process
GO:0022898Regulation of transmembrane transporter activityIDAbiological_process
GO:0030307Positive regulation of cell growthNASbiological_process
GO:0030335Positive regulation of cell migrationISSbiological_process
GO:0031018Endocrine pancreas developmentTASbiological_process
GO:0031904Endosome lumenTAScellular_component
GO:0031954Positive regulation of protein autophosphorylationISSbiological_process
GO:0032148Activation of protein kinase B activityIDAbiological_process
GO:0032270Positive regulation of cellular protein metabolic processIMPbiological_process
GO:0032460Negative regulation of protein oligomerizationIDAbiological_process
GO:0032880Regulation of protein localizationIDAbiological_process
GO:0033861Negative regulation of NAD(P)H oxidase activityIDAbiological_process
GO:0034774Secretory granule lumenTAScellular_component
GO:0042060Wound healingIDAbiological_process
GO:0042177Negative regulation of protein catabolic processIDAbiological_process
GO:0042593Glucose homeostasisIMPbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043410Positive regulation of MAPK cascadeIDAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045429Positive regulation of nitric oxide biosynthetic processNASbiological_process
GO:0045597Positive regulation of cell differentiationNASbiological_process
GO:0045721Negative regulation of gluconeogenesisNASbiological_process
GO:0045725Positive regulation of glycogen biosynthetic processIDAbiological_process
GO:0045740Positive regulation of DNA replicationIDAbiological_process
GO:0045818Negative regulation of glycogen catabolic processIMPbiological_process
GO:0045821Positive regulation of glycolysisIDA IMPbiological_process
GO:0045840Positive regulation of mitosisIDAbiological_process
GO:0045861Negative regulation of proteolysisIMPbiological_process
GO:0045908Negative regulation of vasodilationNASbiological_process
GO:0045909Positive regulation of vasodilationNASbiological_process
GO:0045922Negative regulation of fatty acid metabolic processIMPbiological_process
GO:0046326Positive regulation of glucose importIDAbiological_process
GO:0046628Positive regulation of insulin receptor signaling pathwayIDAbiological_process
GO:0046631Alpha-beta T cell activationIDAbiological_process
GO:0046889Positive regulation of lipid biosynthetic processNASbiological_process
GO:0050708Regulation of protein secretionIDAbiological_process
GO:0050709Negative regulation of protein secretionIDAbiological_process
GO:0050715Positive regulation of cytokine secretionIDAbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0050995Negative regulation of lipid catabolic processNASbiological_process
GO:0051000Positive regulation of nitric-oxide synthase activityNASbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIDAbiological_process
GO:0055089Fatty acid homeostasisIMPbiological_process
GO:0060266Negative regulation of respiratory burst involved in inflammatory responseIDAbiological_process
GO:0060267Positive regulation of respiratory burstIDAbiological_process
GO:0090277Positive regulation of peptide hormone secretionTASbiological_process
GO:0090336Positive regulation of brown fat cell differentiationTASbiological_process
GO:1902176Negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressNASbiological_process
GO:2000252Negative regulation of feeding behaviorIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.84960458190.72512971010.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1330935418
GSE13712_SHEARUp0.0332060206
GSE13712_STATICDown-0.1367331339
GSE19018Up0.1204686799
GSE19899_A1Down-0.0606660204
GSE19899_A2Down-0.1662345112
PubMed_21979375_A1Up0.0222481053
PubMed_21979375_A2Down-0.1401161193
GSE35957Up0.1564613476
GSE36640Up0.2331489294
GSE54402Down-0.0389419684
GSE9593Up0.0912938298
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.1709041405

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

M-CresolDB01776 EXPT01026
MYRISTIC ACIDDB08231 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.