HCSGD entry for INSR
1. General information
| Official gene symbol | INSR |
|---|---|
| Entrez ID | 3643 |
| Gene full name | insulin receptor |
| Other gene symbols | CD220 HHF5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000187 | Activation of MAPK activity | IMP | biological_process |
| GO:0001934 | Positive regulation of protein phosphorylation | IDA | biological_process |
| GO:0003007 | Heart morphogenesis | IMP | biological_process |
| GO:0004713 | Protein tyrosine kinase activity | IDA IMP | molecular_function |
| GO:0004716 | Receptor signaling protein tyrosine kinase activity | IDA | molecular_function |
| GO:0005009 | Insulin-activated receptor activity | IDA | molecular_function |
| GO:0005159 | Insulin-like growth factor receptor binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005525 | GTP binding | IDA | molecular_function |
| GO:0005886 | Plasma membrane | IC TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0005899 | Insulin receptor complex | IMP | cellular_component |
| GO:0005901 | Caveola | IDA | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IDA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IC IDA | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | IDA TAS | biological_process |
| GO:0010008 | Endosome membrane | TAS | cellular_component |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IDA | biological_process |
| GO:0019087 | Transformation of host cell by virus | IMP | biological_process |
| GO:0023014 | Signal transduction by phosphorylation | IDA | biological_process |
| GO:0030238 | Male sex determination | IEA | biological_process |
| GO:0030335 | Positive regulation of cell migration | IMP | biological_process |
| GO:0031017 | Exocrine pancreas development | IEA | biological_process |
| GO:0031994 | Insulin-like growth factor I binding | IPI | molecular_function |
| GO:0031995 | Insulin-like growth factor II binding | IPI | molecular_function |
| GO:0032147 | Activation of protein kinase activity | IMP | biological_process |
| GO:0032148 | Activation of protein kinase B activity | IDA | biological_process |
| GO:0032869 | Cellular response to insulin stimulus | IDA | biological_process |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0042169 | SH2 domain binding | IPI | molecular_function |
| GO:0042593 | Glucose homeostasis | IMP | biological_process |
| GO:0043235 | Receptor complex | IDA | cellular_component |
| GO:0043410 | Positive regulation of MAPK cascade | IMP | biological_process |
| GO:0043548 | Phosphatidylinositol 3-kinase binding | IPI | molecular_function |
| GO:0043559 | Insulin binding | IDA IPI | molecular_function |
| GO:0043560 | Insulin receptor substrate binding | IPI | molecular_function |
| GO:0045429 | Positive regulation of nitric oxide biosynthetic process | IMP | biological_process |
| GO:0045725 | Positive regulation of glycogen biosynthetic process | IDA | biological_process |
| GO:0045740 | Positive regulation of DNA replication | IMP | biological_process |
| GO:0045821 | Positive regulation of glycolysis | IMP | biological_process |
| GO:0045840 | Positive regulation of mitosis | IMP | biological_process |
| GO:0045995 | Regulation of embryonic development | IMP | biological_process |
| GO:0046326 | Positive regulation of glucose import | IDA NAS | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA IMP | biological_process |
| GO:0048639 | Positive regulation of developmental growth | IMP | biological_process |
| GO:0051290 | Protein heterotetramerization | IDA | biological_process |
| GO:0051425 | PTB domain binding | IPI | molecular_function |
| GO:0051897 | Positive regulation of protein kinase B signaling | IMP | biological_process |
| GO:0060267 | Positive regulation of respiratory burst | IDA | biological_process |
| GO:0071363 | Cellular response to growth factor stimulus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2900376429 | 0.0452173512 | 0.9891268204 | 0.3994855082 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3439294679 |
| GSE13712_SHEAR | Down | -1.6036942583 |
| GSE13712_STATIC | Down | -0.5186710813 |
| GSE19018 | Up | 0.5581975610 |
| GSE19899_A1 | Up | 0.0273994631 |
| GSE19899_A2 | Down | -0.8821757304 |
| PubMed_21979375_A1 | Down | -0.8967084325 |
| PubMed_21979375_A2 | Down | -0.3689681361 |
| GSE35957 | Up | 0.0528967103 |
| GSE36640 | Down | -0.8398240180 |
| GSE54402 | Down | -0.1990601539 |
| GSE9593 | Up | 0.2312825487 |
| GSE43922 | Down | -0.0369015801 |
| GSE24585 | Up | 0.2172761227 |
| GSE37065 | Down | -0.1200521032 |
| GSE28863_A1 | Up | 0.8655165016 |
| GSE28863_A2 | Up | 0.5981364298 |
| GSE28863_A3 | Up | 0.3011745670 |
| GSE28863_A4 | Down | -0.0509482758 |
| GSE48662 | Up | 0.5030941202 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Insulin Lispro | DB00046 | BTD00065 | BIOD00065 | DB01310 |
| Insulin Glargine | DB00047 | BTD00045 | BIOD00045 | DB01308 |
| Insulin Pork | DB00071 | BTD00031 | BIOD00031 |
| Mecasermin | DB01277 | - |
| Insulin Aspart | DB01306 | - |
| Insulin Detemir | DB01307 | - |
| Insulin Glulisine | DB01309 | - |
| Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate | DB03909 | EXPT00416 |
| NN344 | DB05115 | - |
| AT1391 | DB05120 | - |
| [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID | DB08513 | - |
| Insulin Degludec | DB09564 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029227 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 12 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22442749 | The downstream target of mTORC1, the kinase S6K1, induces insulin resistance by phosphorylation of insulin receptor substrate-1, thereby increasing the metabolic burden of beta-cells |
| 20819672 | Candidate genes including LMNA, ZMPSTE24, PPAR G, INSR and WRN were sequenced to screen for DNA variants |
| 20634317 | The signaling protein insulin receptor substrate-1 (IRS-1), shown here to be a transcriptional target of Wnt, is induced in this setting |
| 18498745 | In this report, we identified insulin receptor substrate 1 (IRS-1), a critical mediator of the insulin/insulin-like growth factor 1 signaling, as a proteolytic target of the CUL7 E3 ligase in a manner that depends on mammalian target of rapamycin and the p70 S6 kinase activities |
| 15140969 | Concomitantly, these late-passage cervical cells exhibit an increase in sensitivity to IGF-1, including enhanced phosphorylation of the IGF receptor (IGF-R) and insulin receptor substrate as well as increased DNA synthesis (5-fold) and cell proliferation (3 |
| 10764734 | Aged cells presented decreased levels of EGFR, although insulin receptor and transferrin receptor levels were relatively unchanged |
| 8388799 | Human erythrocyte insulin receptor processing is affected by the oxidizing agent menadione |
| 2282079 | Insulin receptor activity and its relationship with catecholamines in rat young, middle aged and old red blood cells were investigated in short term (4-6) weeks and long term (6-8 months) hyperglycemia and hyperinsulinemia |
| 2282079 | Loss of insulin receptor activity is linear with cellular ageing and norepinephrine and epinephrine levels increase with age together with levels of glycosylated hemoglobin in control animals and this correlation is altered in hyperglycemia and hyperinsulinemia |
| 2077476 | Aim of this study was to evaluate the influence of the red cell aging process on insulin receptor binding |
| 2077476 | In erythrocytes from 8 children with high reticulocyte count and 9 healthy age-matched subjects we studied insulin receptor binding in correlation with pyruvate kinase (PK) activity and creatine levels |
| 2077476 | Our results indicate that creatine content is the best marker of red cell age for insulin receptor studies |
| 2201297 | Insulin receptor activity and its relationship with catecholamines in rat young, middle aged and old red blood cells were investigated in experimental hypothyroidism and hyperthyroidism |
| 2201297 | In control animals, a loss of insulin receptor activity was found with cellular ageing and increased levels of norepinephrine, epinephrine and glycosylated hemoglobin |
| 3511057 | Insulin receptor processing as a function of erythrocyte age |
| 3511057 | The effects of cell aging on insulin binding and on insulin receptor processing in human erythrocytes were studied |
| 3511057 | The maximum extent of insulin receptor down-regulation that could be induced decreased linearly with age over the range studied |
| 6388355 | Loss of receptors from cultured cells was accompanied by appearance of a soluble insulin receptor in the medium |
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