HCSGD entry for IRAK1

1. General information

Official gene symbolIRAK1
Entrez ID3654
Gene full nameinterleukin-1 receptor-associated kinase 1
Other gene symbolsIRAK pelle
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0001959Regulation of cytokine-mediated signaling pathwayIMPbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityIDA TASmolecular_function
GO:0004674Protein serine/threonine kinase activityEXP IEA NASmolecular_function
GO:0004704NF-kappaB-inducing kinase activityTASmolecular_function
GO:0004842Ubiquitin-protein ligase activityTASmolecular_function
GO:0005149Interleukin-1 receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005811Lipid particleISScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0007165Signal transductionIEA NASbiological_process
GO:0007178Transmembrane receptor protein serine/threonine kinase signaling pathwayNASbiological_process
GO:0007250Activation of NF-kappaB-inducing kinase activityIDAbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0016301Kinase activityIDAmolecular_function
GO:0016567Protein ubiquitinationTASbiological_process
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0031663Lipopolysaccharide-mediated signaling pathwayIMPbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityIMPbiological_process
GO:0032494Response to peptidoglycanIEAbiological_process
GO:0032496Response to lipopolysaccharideIMPbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayIMP TASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042803Protein homodimerization activityIPI NASmolecular_function
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045323Interleukin-1 receptor complexNAScellular_component
GO:0045893Positive regulation of transcription, DNA-templatedNASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046777Protein autophosphorylationIDA NASbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIEAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDA TASbiological_process
GO:0051259Protein oligomerizationIMPbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
GO:0070498Interleukin-1-mediated signaling pathwayIMPbiological_process
GO:0070555Response to interleukin-1IMPbiological_process
GO:0071456Cellular response to hypoxiaIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02701249570.66977852290.38205045671.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1335574319
GSE13712_SHEARUp0.2036245454
GSE13712_STATICUp0.4600596137
GSE19018Down-0.2320178812
GSE19899_A1Up0.3132967162
GSE19899_A2Up0.4248250235
PubMed_21979375_A1Up1.0354719299
PubMed_21979375_A2Down-0.0350149352
GSE35957Up0.3444090589
GSE36640Down-0.3786467901
GSE54402Up0.6605792601
GSE9593Up0.3461454830
GSE43922Up0.5766954085
GSE24585Down-0.8742922224
GSE37065Down-0.3509813325
GSE28863_A1Down-0.0216080951
GSE28863_A2Up0.3692587446
GSE28863_A3Up0.4656235540
GSE28863_A4Up0.0217011276
GSE48662Up0.3141189798

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL522892CHEMBL33579P51617
CHEMBL1908394CHEMBL33579P51617
CHEMBL124660CHEMBL33579P51617
CHEMBL574738CHEMBL33579P51617
CHEMBL1173655CHEMBL33579P51617
CHEMBL477772CHEMBL33579P51617
CHEMBL1908395CHEMBL33579P51617
CHEMBL1287853CHEMBL33579P51617
CHEMBL379218CHEMBL33579P51617
CHEMBL603469CHEMBL33579P51617
CHEMBL939CHEMBL33579P51617
CHEMBL464552CHEMBL33579P51617
CHEMBL288441CHEMBL33579P51617
CHEMBL1289926CHEMBL33579P51617
CHEMBL1721885CHEMBL33579P51617
CHEMBL450786CHEMBL33579P51617
CHEMBL941CHEMBL33579P51617
CHEMBL475251CHEMBL33579P51617
CHEMBL1908397CHEMBL33579P51617
CHEMBL162CHEMBL33579P51617
CHEMBL1908392CHEMBL33579P51617
CHEMBL31965CHEMBL33579P51617
CHEMBL513909CHEMBL33579P51617
CHEMBL428690CHEMBL33579P51617
CHEMBL24828CHEMBL33579P51617
CHEMBL601719CHEMBL33579P51617
CHEMBL1789941CHEMBL33579P51617
CHEMBL509032CHEMBL33579P51617
CHEMBL535CHEMBL33579P51617
CHEMBL1241674CHEMBL33579P51617
CHEMBL180022CHEMBL33579P51617
CHEMBL210194CHEMBL33579P51617
CHEMBL379787CHEMBL33579P51617
CHEMBL603469CHEMBL33578P51617
CHEMBL124660CHEMBL33578P51617
CHEMBL535CHEMBL33578P51617
CHEMBL401633CHEMBL33578P51617
CHEMBL248757CHEMBL33578P51617
CHEMBL255873CHEMBL33578P51617
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  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-146a-5pMIMAT0000449MIRT000712Western blot//Northern blotFunctional MTI18504431
hsa-miR-146a-5pMIMAT0000449MIRT000712Luciferase reporter assay//Western blotFunctional MTI20061417
hsa-miR-146a-5pMIMAT0000449MIRT000712qRT-PCRFunctional MTI (Weak)18759964
hsa-miR-146a-5pMIMAT0000449MIRT000712qRT-PCR//Western blot//ImmunofluorescenceFunctional MTI19918258
hsa-miR-146a-5pMIMAT0000449MIRT000712Luciferase reporter assay//Microarray//Northern blot//qRT-PCRFunctional MTI16885212
hsa-miR-146a-5pMIMAT0000449MIRT000712ELISA//Luciferase reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI20542134
hsa-miR-146a-5pMIMAT0000449MIRT000712qRT-PCR//Western blotFunctional MTI21178010
hsa-miR-146a-5pMIMAT0000449MIRT000712Luciferase reporter assay//Western blotFunctional MTI21632853
hsa-miR-146a-5pMIMAT0000449MIRT000712Luciferase reporter assayFunctional MTI22593544
hsa-miR-146a-5pMIMAT0000449MIRT000712Western blotFunctional MTI20110513
hsa-miR-146b-5pMIMAT0002809MIRT005395Luciferase reporter assay//Microarray//Northern blot//qRT-PCRFunctional MTI16885212
hsa-miR-215-5pMIMAT0000272MIRT024479MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026216MicroarrayFunctional MTI (Weak)19074876
hsa-miR-1226-3pMIMAT0005577MIRT036505CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037612CLASHFunctional MTI (Weak)23622248
hsa-miR-330-5pMIMAT0004693MIRT038255CLASHFunctional MTI (Weak)23622248
hsa-miR-93-3pMIMAT0004509MIRT038891CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041223CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042485CLASHFunctional MTI (Weak)23622248
hsa-miR-328-3pMIMAT0000752MIRT043810CLASHFunctional MTI (Weak)23622248
hsa-miR-132-3pMIMAT0000426MIRT045847CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046662CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049357CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT051021CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26943583A three-pronged approach has been adopted to assess the if adalimumab is able to: i) modulate a panel of classic and novel senescence- and SASP-associated markers (interleukin [IL]-6, senescence associated-beta-galactosidase, p16/Ink4a, plasminogen activator inhibitor 1, endothelial nitric oxide synthase, miR-146a-5p/Irak1 and miR-126-3p/Spred1) in human umbilical vein endothelial cells (HUVECs); ii) reduce the paracrine effects of senescent HUVECs' secretome on MCF-7 breast cancer cells, through wound healing and mammosphere assay; and iii) exert significant decrease of miR-146a-5p and increase of miR-126-3p in circulating angiogenic cells (CACs) from psoriasis patients receiving adalimumab in monotherapy
23727324We previously reported that a biomarker combination including miR-146a, its target protein IL-1 receptor-associated kinase (IRAK-1), and released interleukin (IL)-6, here collectively designated as MIRAKIL, indicates senescence-associated secretory phenotype (SASP) acquisition by primary human umbilical vein endothelial cells (HUVECs)
23727324However, short-term CoQ10H(2) supplementation attenuated LPS-induced MIRAKIL changes in young cells; in senescent cells CoQ10H(2) supplementation significantly attenuated LPS-induced miR-146a and IRAK-1 modulation but failed to curb IL-6 release
23252865We also observed that the expressions of IRAK1 and TRAF6, the targets of miR-146a, and DC-SIGN, a target of miR-155 were diminished while miR-146a and miR-155 were augmented during aging
23252865In addition, we found that the production of pro-inflammatory cytokines, which is mediated by the activation of NF-kB pathway via IRAK1 and TRAF6, was greatly reduced in aged BMDC
22692818Mimic and antagomir transfection confirmed TLR's IL-1 receptor-associated kinase (IRAK1) protein modulation in both young and senescent cells
22692818Interestingly, a 1,000-fold increased expression of miR-146a was observed in CACs of CHF patients compared to CTR, along with decreased expression of IRAK1 protein
20053980Protein levels of IRAK1 and PAI-1 were analyzed by Western blot and those of IL6 and IL8 by ELISA
20053980Overexpression of either IRAK1 or PAI-1 inhibited the effects of miR-146a on cell proliferation and iROS production in senescent cells
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