HCSGD entry for ITGAM

1. General information

Official gene symbolITGAM
Entrez ID3684
Gene full nameintegrin, alpha M (complement component 3 receptor 3 subunit)
Other gene symbolsCD11B CR3A MAC-1 MAC1A MO1A SLEB6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001846Opsonin bindingIEAmolecular_function
GO:0001948Glycoprotein bindingIPImolecular_function
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007155Cell adhesionTASbiological_process
GO:0007159Leukocyte cell-cell adhesionIEAbiological_process
GO:0007229Integrin-mediated signaling pathwayIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008201Heparin bindingIEAmolecular_function
GO:0008305Integrin complexIEAcellular_component
GO:0009897External side of plasma membraneIEAcellular_component
GO:0014005Microglia developmentIEAbiological_process
GO:0030593Neutrophil chemotaxisIEAbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0043395Heparan sulfate proteoglycan bindingIEAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045123Cellular extravasationIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0050798Activated T cell proliferationIEAbiological_process
GO:0050900Leukocyte migrationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.72584260860.85452049310.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0774258637
GSE13712_SHEARDown-0.0243545660
GSE13712_STATICDown-0.0137987172
GSE19018Up0.0334905856
GSE19899_A1Up0.1307928748
GSE19899_A2Up0.1202893340
PubMed_21979375_A1Down-0.0226426780
PubMed_21979375_A2Down-0.0262000765
GSE35957Up0.1592956964
GSE36640Up0.1177895110
GSE54402Up0.0503653553
GSE9593Down-0.1445133415
GSE43922Up0.0118275794
GSE24585Up0.0895863337
GSE37065Up0.0036462725
GSE28863_A1Down-0.0229737910
GSE28863_A2Up0.0186637939
GSE28863_A3Up0.2752189040
GSE28863_A4Down-0.0279841229
GSE48662Down-0.0720648636

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25892207TERC knockout (KO) mice had a significantly reduced number of CD11b(+) microglia in the dentate gyrus
241703702%, respectively; all cells were negative for CD11b, CD19, and CD45
23974111Erlotinib and gefitinib alone did not promote differentiation, yet stimulated the acquisition of morphological and biochemical maturation markers (including the expression of CD11b and CD14 as well as increased NADPH oxidase activity) when combined with either ATRA or VD
23461802CD11b expression was highest in neutrophils exposed to supernatant from RTH WB RBCs (p < 0
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