HCSGD entry for ITGAV

1. General information

Official gene symbolITGAV
Entrez ID3685
Gene full nameintegrin, alpha V
Other gene symbolsCD51 MSK8 VNRA VTNR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEPbiological_process
GO:0001618Virus receptor activityIEAmolecular_function
GO:0001846Opsonin bindingISSmolecular_function
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005080Protein kinase C bindingISSmolecular_function
GO:0005245Voltage-gated calcium channel activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0007155Cell adhesionIDAbiological_process
GO:0007160Cell-matrix adhesionNASbiological_process
GO:0007229Integrin-mediated signaling pathwayNASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008305Integrin complexIDA NAScellular_component
GO:0009897External side of plasma membraneIEAcellular_component
GO:0009986Cell surfaceIDA ISScellular_component
GO:0010745Negative regulation of macrophage derived foam cell differentiationIMPbiological_process
GO:0010888Negative regulation of lipid storageIMPbiological_process
GO:0016020MembraneISScellular_component
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030335Positive regulation of cell migrationIEAbiological_process
GO:0031994Insulin-like growth factor I bindingIDAmolecular_function
GO:0032369Negative regulation of lipid transportIMPbiological_process
GO:0033690Positive regulation of osteoblast proliferationIEAbiological_process
GO:0034765Regulation of ion transmembrane transportIDAbiological_process
GO:0035867Alphav-beta3 integrin-IGF-1-IGF1R complexIDAcellular_component
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0043277Apoptotic cell clearanceIEAbiological_process
GO:0045335Phagocytic vesicleTAScellular_component
GO:0045715Negative regulation of low-density lipoprotein particle receptor biosynthetic processIMPbiological_process
GO:0045785Positive regulation of cell adhesionIDAbiological_process
GO:0046718Viral entry into host cellTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050431Transforming growth factor beta bindingISSmolecular_function
GO:0050748Negative regulation of lipoprotein metabolic processIMPbiological_process
GO:0050764Regulation of phagocytosisIDAbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0052066Entry of symbiont into host cell by promotion of host phagocytosisNASbiological_process
GO:0070371ERK1 and ERK2 cascadeISSbiological_process
GO:0070588Calcium ion transmembrane transportIDAbiological_process
GO:0097192Extrinsic apoptotic signaling pathway in absence of ligandISSbiological_process
GO:2000425Regulation of apoptotic cell clearanceISSbiological_process
GO:2000536Negative regulation of entry of bacterium into host cellIDAbiological_process
GO:2001237Negative regulation of extrinsic apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42742441020.03946763800.99999024730.3746204398

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3369744748
GSE13712_SHEARUp0.3608936792
GSE13712_STATICUp0.1816605231
GSE19018Up0.0969702789
GSE19899_A1Down-0.5045481529
GSE19899_A2Down-1.0686112608
PubMed_21979375_A1Down-0.6489406697
PubMed_21979375_A2Down-1.0624441878
GSE35957Up0.5056292716
GSE36640Up0.4252463835
GSE54402Down-0.3873114069
GSE9593Down-0.0564956183
GSE43922Down-0.5049811300
GSE24585Up0.7539253313
GSE37065Up0.0892416029
GSE28863_A1Up0.1466569406
GSE28863_A2Up0.4050654142
GSE28863_A3Down-0.4523799082
GSE28863_A4Down-0.3544119866
GSE48662Up0.0341737386

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Anti-thymocyte Globulin (Rabbit)DB00098 BTD00040 | BIOD00040

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-142-3pMIMAT0000434MIRT021641MicroarrayFunctional MTI (Weak)17612493
hsa-miR-215-5pMIMAT0000272MIRT024872MicroarrayFunctional MTI (Weak)19074876
hsa-miR-196a-5pMIMAT0000226MIRT026088SequencingFunctional MTI (Weak)20371350
hsa-miR-192-5pMIMAT0000222MIRT026587MicroarrayFunctional MTI (Weak)19074876
hsa-miR-32-5pMIMAT0000090MIRT028372SequencingFunctional MTI (Weak)20371350
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.