HCSGD entry for CD82

1. General information

Official gene symbolCD82
Entrez ID3732
Gene full nameCD82 molecule
Other gene symbols4F9 C33 GR15 IA4 KAI1 R2 SAR2 ST6 TSPAN27
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00052166330.98795641500.06387395351.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3701179267
GSE13712_SHEARUp0.0498897676
GSE13712_STATICUp0.0846497313
GSE19018Down-0.2426673504
GSE19899_A1Up1.2824158335
GSE19899_A2Up1.8702342739
PubMed_21979375_A1Up0.6264060966
PubMed_21979375_A2Up1.3816426709
GSE35957Down-0.8345776592
GSE36640Up0.4469334138
GSE54402Up1.0313746543
GSE9593Up2.0126300810
GSE43922Up1.5805115440
GSE24585Up0.1456640191
GSE37065Up0.7273335621
GSE28863_A1Down-0.0115416169
GSE28863_A2Up0.2984533896
GSE28863_A3Up0.2285194606
GSE28863_A4Up0.3444105167
GSE48662Up0.7881202107

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23873025CD82/KAI expression prevents IL-8-mediated endothelial gap formation in late-stage melanomas
23873025However, little is known about the role of CD82 tetraspanins in malignant melanomas during cancer cell invasion
23873025In this study, we investigated the functional importance of CD82 expression in melanoma-mediated gap formation by using cDNAs to induce CD82 expression in highly invasive melanoma cell lines
23873025Results showed that CD82 expression inhibited melanoma cell-induced gap formation, melanoma cell extravasation in vitro and subsequent lung metastasis development in vivo
23873025Mechanistic studies showed that inducible expression of CD82 in highly metastatic melanoma cells significantly increased p21 expression upon binding of Duffy antigen receptor group (DARC), inducing tumor cell senescence and interrupting IL-8-mediated vascular endothelial (VE)-cadherin disassembly
23873025Taken together, these studies provide a rationale for using drug therapies that restore CD82 expression and inhibit IL-8 production to inhibit late-stage melanoma cell extravasation and subsequent metastasis development
18505570We also report that this phosphatase is highly expressed in several cervix cancer cell lines such as HeLa, SiHa, CaSki, C33 and HT3 compared to primary keratinocytes
21552918Representative cell lines (C-4 I, ME-180 and C-33 A) were selected for this study on the basis of their various expression levels of either wild-type or mutated p53, and also of their content of integrated human papillomavirus sequences
21552918In the case of C-33 A, the presence of high levels of mutant p53 prevented the exogenous wild-type p53 from causing any significant modulatory action on their proliferation or neoplastic phenotype
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