HCSGD entry for KCNE1

1. General information

Official gene symbolKCNE1
Entrez ID3753
Gene full namepotassium voltage-gated channel, Isk-related family, member 1
Other gene symbolsISK JLNS JLNS2 LQT2/5 LQT5 MinK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002070Epithelial cell maturationIEAbiological_process
GO:0005249Voltage-gated potassium channel activityIDAmolecular_function
GO:0005251Delayed rectifier potassium channel activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005764LysosomeIDAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006487Protein N-linked glycosylationIDAbiological_process
GO:0006493Protein O-linked glycosylationIDAbiological_process
GO:0007605Sensory perception of soundTASbiological_process
GO:0008076Voltage-gated potassium channel complexIC IDAcellular_component
GO:0008584Male gonad developmentIEAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0015459Potassium channel regulator activityIDAmolecular_function
GO:0016324Apical plasma membraneIEAcellular_component
GO:0030018Z discISScellular_component
GO:0031433Telethonin bindingIPImolecular_function
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0060047Heart contractionIEAbiological_process
GO:0060307Regulation of ventricular cardiac muscle cell membrane repolarizationIMPbiological_process
GO:0071320Cellular response to cAMPIDAbiological_process
GO:0071435Potassium ion exportIDAbiological_process
GO:0071468Cellular response to acidityIEAbiological_process
GO:0071805Potassium ion transmembrane transportIDAbiological_process
GO:0086002Cardiac muscle cell action potential involved in contractionIMPbiological_process
GO:0086005Ventricular cardiac muscle cell action potentialIMPbiological_process
GO:0086008Voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarizationIDAmolecular_function
GO:0086009Membrane repolarizationIDAbiological_process
GO:0086011Membrane repolarization during action potentialIDAbiological_process
GO:0086013Membrane repolarization during cardiac muscle cell action potentialIDA IMPbiological_process
GO:0086091Regulation of heart rate by cardiac conductionIMPbiological_process
GO:0090315Negative regulation of protein targeting to membraneIEAbiological_process
GO:1901379Regulation of potassium ion transmembrane transportIDAbiological_process
GO:1901381Positive regulation of potassium ion transmembrane transportIDAbiological_process
GO:1902259Regulation of delayed rectifier potassium channel activityIDAbiological_process
GO:1902282Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationIMPmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.78082469890.39990844190.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0583996264
GSE13712_SHEARDown-0.0531989247
GSE13712_STATICDown-0.0466189161
GSE19018Down-0.0075537308
GSE19899_A1Up0.0122404118
GSE19899_A2Down-0.2362616891
PubMed_21979375_A1Down-0.1881928762
PubMed_21979375_A2Down-0.2035248615
GSE35957Down-0.1284447637
GSE36640Down-0.1507134269
GSE54402Down-0.4478443098
GSE9593Up0.1587926485
GSE43922Down-0.2636706344
GSE24585Down-0.1102787831
GSE37065Up0.1888213557
GSE28863_A1Up0.0936472835
GSE28863_A2Up0.1043030239
GSE28863_A3Up0.4455676590
GSE28863_A4Up0.1245697743
GSE48662Up0.0877693272

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

IndapamideDB00808 APRD01031
AzimilideDB04957 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT002924Luciferase reporter assay//Western blot//5'RACE//Real time RT-PCRFunctional MTI17443681
hsa-miR-1MIMAT0000416MIRT002924qRT-PCRFunctional MTI (Weak)21169019
hsa-miR-361-3pMIMAT0004682MIRT038264CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-1MIMAT00004161hsa-miR-1{Western blot}{Western blot}{Western blot}{overexpression by mature miRNA transfection}{underexpression by anti-miRNA oligonucleotides}{mutation}17443681
hsa-miR-1MIMAT00004163hsa-miR-1{Western blot}{Western blot}{Western blot}{overexpression by mature miRNA transfection}{underexpression by anti-miRNA oligonucleotides}{mutation}17443681
hsa-miR-1MIMAT00004162hsa-miR-1{Western blot}{Western blot}{Western blot}{overexpression by mature miRNA transfection}{underexpression by anti-miRNA oligonucleotides}{mutation}17443681
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.