HCSGD entry for KCNH1
1. General information
| Official gene symbol | KCNH1 |
|---|---|
| Entrez ID | 3756 |
| Gene full name | potassium voltage-gated channel, subfamily H (eag-related), member 1 |
| Other gene symbols | EAG EAG1 Kv10.1 h-eag |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000155 | Phosphorelay sensor kinase activity | IEA | molecular_function |
| GO:0005251 | Delayed rectifier potassium channel activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005637 | Nuclear inner membrane | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006813 | Potassium ion transport | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007520 | Myoblast fusion | TAS | biological_process |
| GO:0008076 | Voltage-gated potassium channel complex | TAS | cellular_component |
| GO:0042391 | Regulation of membrane potential | IBA | biological_process |
| GO:0071805 | Potassium ion transmembrane transport | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8105752327 | 0.4102483606 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0113179154 |
| GSE13712_SHEAR | Up | 0.0317162838 |
| GSE13712_STATIC | Down | -0.0819495529 |
| GSE19018 | Up | 0.0709859452 |
| GSE19899_A1 | Up | 0.0347896369 |
| GSE19899_A2 | Down | -0.0417012662 |
| PubMed_21979375_A1 | Down | -0.0739397133 |
| PubMed_21979375_A2 | Down | -0.1156258678 |
| GSE35957 | Down | -0.0040886964 |
| GSE36640 | Up | 0.2130844152 |
| GSE54402 | Up | 0.1311825322 |
| GSE9593 | Down | -0.1116377457 |
| GSE43922 | Up | 0.0152795844 |
| GSE24585 | Down | -0.3120743679 |
| GSE37065 | Down | -0.8218365338 |
| GSE28863_A1 | Down | -0.0183658871 |
| GSE28863_A2 | Up | 0.1105314753 |
| GSE28863_A3 | Up | 0.2504069389 |
| GSE28863_A4 | Down | -0.0056584935 |
| GSE48662 | Up | 0.2304692807 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-296-3p | MIMAT0004679 | MIRT006973 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22999387 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018512 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
