HCSGD entry for KCNJ1
1. General information
| Official gene symbol | KCNJ1 |
|---|---|
| Entrez ID | 3758 |
| Gene full name | potassium inwardly-rectifying channel, subfamily J, member 1 |
| Other gene symbols | KIR1.1 ROMK ROMK1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001822 | Kidney development | IEA | biological_process |
| GO:0001894 | Tissue homeostasis | IEA | biological_process |
| GO:0005242 | Inward rectifier potassium channel activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005546 | Phosphatidylinositol-4,5-bisphosphate binding | IDA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006813 | Potassium ion transport | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007588 | Excretion | TAS | biological_process |
| GO:0008076 | Voltage-gated potassium channel complex | TAS | cellular_component |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0070294 | Renal sodium ion absorption | IEA | biological_process |
| GO:0071805 | Potassium ion transmembrane transport | TAS | biological_process |
| GO:0072358 | Cardiovascular system development | IEA | biological_process |
| GO:1900128 | Regulation of G-protein activated inward rectifier potassium channel activity | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6031931462 | 0.7820797994 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0022577699 |
| GSE13712_SHEAR | Down | -0.0747515527 |
| GSE13712_STATIC | Down | -0.1362349421 |
| GSE19018 | Up | 0.0953832283 |
| GSE19899_A1 | Up | 0.0956312556 |
| GSE19899_A2 | Down | -0.0676159368 |
| PubMed_21979375_A1 | Up | 0.0194420524 |
| PubMed_21979375_A2 | Down | -0.2287841026 |
| GSE35957 | Up | 0.1176306490 |
| GSE36640 | Up | 0.1430780721 |
| GSE54402 | Down | -0.0650097142 |
| GSE9593 | Up | 0.0200352782 |
| GSE43922 | Up | 0.0133152163 |
| GSE24585 | Up | 0.2812659824 |
| GSE37065 | Down | -0.0813136677 |
| GSE28863_A1 | Up | 0.2624528602 |
| GSE28863_A2 | Up | 0.2175919427 |
| GSE28863_A3 | Up | 0.1346076182 |
| GSE28863_A4 | Down | -0.0233014202 |
| GSE48662 | Up | 0.0100208241 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Bethanidine | DB00217 | APRD00825 |
| Glimepiride | DB00222 | APRD00381 |
| Minoxidil | DB00350 | APRD00086 | DB08225 |
| Glycodiazine | DB01382 | - |
| Agmatine | DB08838 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20841375 | In the present study, we show that knockdown of the inwardly rectifying K(+) channel Kir2 |
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