HCSGD entry for KCNJ4
1. General information
| Official gene symbol | KCNJ4 |
|---|---|
| Entrez ID | 3761 |
| Gene full name | potassium inwardly-rectifying channel, subfamily J, member 4 |
| Other gene symbols | HIR HIRK2 HRK1 IRK-3 IRK3 Kir2.3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005242 | Inward rectifier potassium channel activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006813 | Potassium ion transport | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0008076 | Voltage-gated potassium channel complex | TAS | cellular_component |
| GO:0016323 | Basolateral plasma membrane | IDA | cellular_component |
| GO:0030165 | PDZ domain binding | IPI | molecular_function |
| GO:0030659 | Cytoplasmic vesicle membrane | IEA | cellular_component |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0071805 | Potassium ion transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1088114091 | 0.9575862999 | 0.6834853327 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0133971665 |
| GSE13712_SHEAR | Up | 0.0390685619 |
| GSE13712_STATIC | Down | -0.1371646029 |
| GSE19018 | Up | 0.0339494609 |
| GSE19899_A1 | Down | -0.0365987779 |
| GSE19899_A2 | Up | 0.2128229151 |
| PubMed_21979375_A1 | Down | -0.1191221005 |
| PubMed_21979375_A2 | Down | -0.1128437785 |
| GSE35957 | Up | 0.0822197730 |
| GSE36640 | Up | 0.2113130964 |
| GSE54402 | Up | 0.0515610279 |
| GSE9593 | Down | -0.0109150167 |
| GSE43922 | Up | 0.2021857259 |
| GSE24585 | Up | 0.1558585134 |
| GSE37065 | Down | -0.0240409375 |
| GSE28863_A1 | Up | 0.1923895666 |
| GSE28863_A2 | Up | 0.2549379234 |
| GSE28863_A3 | Up | 0.8560055560 |
| GSE28863_A4 | Up | 0.3535371038 |
| GSE48662 | Up | 0.1110650597 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24459729 | A global requirement for the HIR complex in the assembly of chromatin |
| 24459729 | In this review, we discuss the roles of an evolutionarily conserved histone chaperone known as the HIR/HIRA complex |
| 24459729 | This review presents an overview of the role of the HIR complex, in yeast as well as other organisms, in each of these processes, in order to give a better understanding of how nucleosome assembly is imperative for cellular homeostasis and genomic integrity |
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