HCSGD entry for KIF2A


1. General information

Official gene symbolKIF2A
Entrez ID3796
Gene full namekinesin heavy chain member 2A
Other gene symbolsHK2 KIF2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000278Mitotic cell cycleTASbiological_process
GO:0000922Spindle poleIDAcellular_component
GO:0003774Motor activityTASmolecular_function
GO:0003777Microtubule motor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005871Kinesin complexIEAcellular_component
GO:0005876Spindle microtubuleIDAcellular_component
GO:0007018Microtubule-based movementIEA TASbiological_process
GO:0007052Mitotic spindle organizationIDAbiological_process
GO:0007067MitosisIEAbiological_process
GO:0007399Nervous system developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008017Microtubule bindingIEAmolecular_function
GO:0008152Metabolic processTASbiological_process
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0030154Cell differentiationIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.90759947950.03495082630.99999024730.3534241644

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3080766308
GSE13712_SHEARUp0.0943809194
GSE13712_STATICDown-0.1566305022
GSE19018Down-0.4796890060
GSE19899_A1Down-0.4069549014
GSE19899_A2Down-0.5379766852
PubMed_21979375_A1Up0.3543008327
PubMed_21979375_A2Down-0.5982077968
GSE35957Down-0.4399279455
GSE36640Down-0.7655999678
GSE54402Up0.1014428134
GSE9593Up0.0357712019
GSE43922Down-0.4327566879
GSE24585Up0.0315074007
GSE37065Up0.0175788024
GSE28863_A1Up0.1051422117
GSE28863_A2Up0.3490883793
GSE28863_A3Down-0.4441973422
GSE28863_A4Down-0.0611886829
GSE48662Down-0.7176690639

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT003853Luciferase reporter assay//MicroarrayFunctional MTI15685193
hsa-miR-1MIMAT0000416MIRT003853pSILAC//ProteomicsFunctional MTI (Weak)18668040
hsa-miR-1MIMAT0000416MIRT003853Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-183-5pMIMAT0000261MIRT004016Immunoblot//Immunocytochemistry//Luciferase reporter assay//qRT-PCR//Reporter assay;OtherFunctional MTI19940135
hsa-miR-34a-5pMIMAT0000255MIRT025350ProteomicsFunctional MTI (Weak)21566225
hsa-miR-16-5pMIMAT0000069MIRT031888ProteomicsFunctional MTI (Weak)18668040
hsa-let-7b-5pMIMAT0000063MIRT032432ProteomicsFunctional MTI (Weak)18668040
hsa-miR-615-3pMIMAT0003283MIRT039652CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-1MIMAT0000416NAhsa-miR-115685193
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19940135To gain insight into the biological roles of miR-183 we investigated two potential novel targets: integrin beta1 (ITGB1) and kinesin 2alpha (KIF2A)
19940135Targeting of the 3'-untranslated region (3'-UTR) of ITGB1 and KIF2A by miR-183 was confirmed by luciferase assay
19940135Targeting of KIF2A by miR-183 resulted in some increase in the formation of cells with monopolar spindles in HeLa cells but not in human diploid fibroblast or human trabecular meshwork cells
Entries Per Page
Displaying Page of