HCSGD entry for RHOC
1. General information
| Official gene symbol | RHOC |
|---|---|
| Entrez ID | 389 |
| Gene full name | ras homolog family member C |
| Other gene symbols | ARH9 ARHC H9 RHOH9 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000910 | Cytokinesis | IDA | biological_process |
| GO:0004871 | Signal transducer activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA TAS | cellular_component |
| GO:0007264 | Small GTPase mediated signal transduction | IEA TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0032154 | Cleavage furrow | IDA | cellular_component |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IMP | biological_process |
| GO:0043297 | Apical junction assembly | IDA IEA | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6376885681 | 0.1446553512 | 0.9999902473 | 0.7324205424 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2019896569 |
| GSE13712_SHEAR | Up | 0.2561428611 |
| GSE13712_STATIC | Up | 0.2679244569 |
| GSE19018 | Down | -0.1077790212 |
| GSE19899_A1 | Down | -0.0442794607 |
| GSE19899_A2 | Down | -0.2234803531 |
| PubMed_21979375_A1 | Up | 0.4882931631 |
| PubMed_21979375_A2 | Up | 0.1229468311 |
| GSE35957 | Down | -0.4203568682 |
| GSE36640 | Down | -0.1693281811 |
| GSE54402 | Down | -0.4169301262 |
| GSE9593 | Up | 0.2048316571 |
| GSE43922 | Up | 0.0447204881 |
| GSE24585 | Up | 0.3218026048 |
| GSE37065 | Down | -0.0178908501 |
| GSE28863_A1 | Down | -0.5413629330 |
| GSE28863_A2 | Down | -0.4280638254 |
| GSE28863_A3 | Down | -0.2777760669 |
| GSE28863_A4 | Down | -0.2198340335 |
| GSE48662 | Up | 0.0110965730 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-138-5p | MIMAT0000430 | MIRT000495 | qRT-PCR//Luciferase reporter assay//Western blot//Reporter assay | Functional MTI | 20232393 |
| hsa-miR-138-5p | MIMAT0000430 | MIRT000495 | qRT-PCR | Functional MTI (Weak) | 21770894 |
| hsa-miR-138-5p | MIMAT0000430 | MIRT000495 | Luciferase reporter assay | Functional MTI | 23007504 |
| hsa-miR-372-3p | MIMAT0000724 | MIRT005932 | Immunocytochemistry//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 21490602 |
| hsa-miR-302b-3p | MIMAT0000715 | MIRT005933 | Immunocytochemistry//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 21490602 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022794 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023854 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-455-3p | MIMAT0004784 | MIRT037911 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-138-5p | MIMAT0000430 | 1 | hsa-miR-138 | {Western blot} | {overexpression by miRNA mimics tranfection} | 20232393 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
