HCSGD entry for LBP
1. General information
Official gene symbol | LBP |
---|---|
Entrez ID | 3929 |
Gene full name | lipopolysaccharide binding protein |
Other gene symbols | BPIFD2 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0001530 | Lipopolysaccharide binding | IDA ISS | molecular_function |
GO:0002224 | Toll-like receptor signaling pathway | TAS | biological_process |
GO:0002232 | Leukocyte chemotaxis involved in inflammatory response | IEA | biological_process |
GO:0002281 | Macrophage activation involved in immune response | ISS | biological_process |
GO:0005102 | Receptor binding | ISS | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005576 | Extracellular region | TAS | cellular_component |
GO:0005615 | Extracellular space | IDA ISS | cellular_component |
GO:0006953 | Acute-phase response | IEP ISS | biological_process |
GO:0006968 | Cellular defense response | ISS | biological_process |
GO:0008228 | Opsonization | IC ISS | biological_process |
GO:0009986 | Cell surface | IDA | cellular_component |
GO:0015920 | Lipopolysaccharide transport | IDA | biological_process |
GO:0031663 | Lipopolysaccharide-mediated signaling pathway | IDA | biological_process |
GO:0032490 | Detection of molecule of bacterial origin | IDA | biological_process |
GO:0032496 | Response to lipopolysaccharide | IDA | biological_process |
GO:0032720 | Negative regulation of tumor necrosis factor production | IDA | biological_process |
GO:0032722 | Positive regulation of chemokine production | IEA | biological_process |
GO:0032755 | Positive regulation of interleukin-6 production | IDA | biological_process |
GO:0032757 | Positive regulation of interleukin-8 production | IDA | biological_process |
GO:0032760 | Positive regulation of tumor necrosis factor production | IDA ISS | biological_process |
GO:0034142 | Toll-like receptor 4 signaling pathway | TAS | biological_process |
GO:0034145 | Positive regulation of toll-like receptor 4 signaling pathway | IDA | biological_process |
GO:0042535 | Positive regulation of tumor necrosis factor biosynthetic process | IEA | biological_process |
GO:0043032 | Positive regulation of macrophage activation | IDA | biological_process |
GO:0044130 | Negative regulation of growth of symbiont in host | IEA | biological_process |
GO:0045087 | Innate immune response | IC ISS TAS | biological_process |
GO:0050829 | Defense response to Gram-negative bacterium | IDA ISS | biological_process |
GO:0050830 | Defense response to Gram-positive bacterium | IDA | biological_process |
GO:0060265 | Positive regulation of respiratory burst involved in inflammatory response | ISS | biological_process |
GO:0070891 | Lipoteichoic acid binding | IDA | molecular_function |
GO:0071222 | Cellular response to lipopolysaccharide | IDA | biological_process |
GO:0071223 | Cellular response to lipoteichoic acid | IDA | biological_process |
GO:0090023 | Positive regulation of neutrophil chemotaxis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.2568205691 | 0.4681583716 | 0.9498066882 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Up | 0.0754343888 |
GSE13712_SHEAR | Up | 0.0921429894 |
GSE13712_STATIC | Down | -0.0052987685 |
GSE19018 | Up | 0.0271135584 |
GSE19899_A1 | Up | 0.0513701935 |
GSE19899_A2 | Down | -0.0650874408 |
PubMed_21979375_A1 | Up | 0.0639959851 |
PubMed_21979375_A2 | Down | -0.0702032275 |
GSE35957 | Down | -0.0503699817 |
GSE36640 | Up | 0.1399171624 |
GSE54402 | Down | -0.0119665478 |
GSE9593 | Down | -2.0028159801 |
GSE43922 | Up | 0.0112044074 |
GSE24585 | Up | 0.0358602814 |
GSE37065 | Up | 0.9377165966 |
GSE28863_A1 | Down | -0.0676530168 |
GSE28863_A2 | Up | 1.0132948015 |
GSE28863_A3 | Up | 0.2651703824 |
GSE28863_A4 | Up | 0.0316341643 |
GSE48662 | Down | -0.0221935293 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-335-5p | MIMAT0000765 | MIRT017289 | Microarray | Functional MTI (Weak) | 18185580 |
hsa-miR-186-5p | MIMAT0000456 | MIRT045133 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-22-3p | MIMAT0000077 | MIRT050450 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
21764698 | OBJECTIVE: To investigate the role of lycium bararum polysaccharides (LBP) on angiotensin II (AngII)-induced senescence of human umbilical vein endothelial cells (HUVECs) and expressions of P53 and P16 and explore the mechanism of LBP against aging |
21764698 | OBJECTIVE: To investigate the role of lycium bararum polysaccharides (LBP) on angiotensin II (AngII)-induced senescence of human umbilical vein endothelial cells (HUVECs) and expressions of P53 and P16 and explore the mechanism of LBP against aging |
21764698 | LBP treatment of AngII-exposed cells resulted in decreased beta-gal-positive cells with a reduction in G(0)/G(1) phase cells and an increase in S phase cells |
21764698 | LBP treatment also increased the cell viability and significantly decreased the expression levels of P53 and P16 (P<0 |
19737142 | Bacterial translocation was evaluated by serum levels of lipopolysaccharide binding protein (LBP) |
19737142 | Bacterial translocation was evaluated by serum levels of lipopolysaccharide binding protein (LBP) |
19737142 | With respect to these proportions, there were no significant differences between patients in function of the presence or absence of decompensation or in function of the increased or normal values of LBP |
19737142 | Conversely, those patients with elevated levels of LBP presented a significantly higher frequency of regulatory T cells than those with normal levels |
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