HCSGD entry for LBP


1. General information

Official gene symbolLBP
Entrez ID3929
Gene full namelipopolysaccharide binding protein
Other gene symbolsBPIFD2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001530Lipopolysaccharide bindingIDA ISSmolecular_function
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002232Leukocyte chemotaxis involved in inflammatory responseIEAbiological_process
GO:0002281Macrophage activation involved in immune responseISSbiological_process
GO:0005102Receptor bindingISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDA ISScellular_component
GO:0006953Acute-phase responseIEP ISSbiological_process
GO:0006968Cellular defense responseISSbiological_process
GO:0008228OpsonizationIC ISSbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0015920Lipopolysaccharide transportIDAbiological_process
GO:0031663Lipopolysaccharide-mediated signaling pathwayIDAbiological_process
GO:0032490Detection of molecule of bacterial originIDAbiological_process
GO:0032496Response to lipopolysaccharideIDAbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIDAbiological_process
GO:0032722Positive regulation of chemokine productionIEAbiological_process
GO:0032755Positive regulation of interleukin-6 productionIDAbiological_process
GO:0032757Positive regulation of interleukin-8 productionIDAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIDA ISSbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034145Positive regulation of toll-like receptor 4 signaling pathwayIDAbiological_process
GO:0042535Positive regulation of tumor necrosis factor biosynthetic processIEAbiological_process
GO:0043032Positive regulation of macrophage activationIDAbiological_process
GO:0044130Negative regulation of growth of symbiont in hostIEAbiological_process
GO:0045087Innate immune responseIC ISS TASbiological_process
GO:0050829Defense response to Gram-negative bacteriumIDA ISSbiological_process
GO:0050830Defense response to Gram-positive bacteriumIDAbiological_process
GO:0060265Positive regulation of respiratory burst involved in inflammatory responseISSbiological_process
GO:0070891Lipoteichoic acid bindingIDAmolecular_function
GO:0071222Cellular response to lipopolysaccharideIDAbiological_process
GO:0071223Cellular response to lipoteichoic acidIDAbiological_process
GO:0090023Positive regulation of neutrophil chemotaxisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.25682056910.46815837160.94980668821.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0754343888
GSE13712_SHEARUp0.0921429894
GSE13712_STATICDown-0.0052987685
GSE19018Up0.0271135584
GSE19899_A1Up0.0513701935
GSE19899_A2Down-0.0650874408
PubMed_21979375_A1Up0.0639959851
PubMed_21979375_A2Down-0.0702032275
GSE35957Down-0.0503699817
GSE36640Up0.1399171624
GSE54402Down-0.0119665478
GSE9593Down-2.0028159801
GSE43922Up0.0112044074
GSE24585Up0.0358602814
GSE37065Up0.9377165966
GSE28863_A1Down-0.0676530168
GSE28863_A2Up1.0132948015
GSE28863_A3Up0.2651703824
GSE28863_A4Up0.0316341643
GSE48662Down-0.0221935293

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017289MicroarrayFunctional MTI (Weak)18185580
hsa-miR-186-5pMIMAT0000456MIRT045133CLASHFunctional MTI (Weak)23622248
hsa-miR-22-3pMIMAT0000077MIRT050450CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21764698OBJECTIVE: To investigate the role of lycium bararum polysaccharides (LBP) on angiotensin II (AngII)-induced senescence of human umbilical vein endothelial cells (HUVECs) and expressions of P53 and P16 and explore the mechanism of LBP against aging
21764698OBJECTIVE: To investigate the role of lycium bararum polysaccharides (LBP) on angiotensin II (AngII)-induced senescence of human umbilical vein endothelial cells (HUVECs) and expressions of P53 and P16 and explore the mechanism of LBP against aging
21764698LBP treatment of AngII-exposed cells resulted in decreased beta-gal-positive cells with a reduction in G(0)/G(1) phase cells and an increase in S phase cells
21764698LBP treatment also increased the cell viability and significantly decreased the expression levels of P53 and P16 (P<0
19737142Bacterial translocation was evaluated by serum levels of lipopolysaccharide binding protein (LBP)
19737142Bacterial translocation was evaluated by serum levels of lipopolysaccharide binding protein (LBP)
19737142With respect to these proportions, there were no significant differences between patients in function of the presence or absence of decompensation or in function of the increased or normal values of LBP
19737142Conversely, those patients with elevated levels of LBP presented a significantly higher frequency of regulatory T cells than those with normal levels
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