HCSGD entry for SMAD7

1. General information

Official gene symbolSMAD7
Entrez ID4092
Gene full nameSMAD family member 7
Other gene symbolsCRCS3 MADH7 MADH8
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0001657Ureteric bud developmentIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005518Collagen bindingIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005913Cell-cell adherens junctionIDAcellular_component
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIEA TASbiological_process
GO:0008013Beta-catenin bindingIPImolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0010719Negative regulation of epithelial to mesenchymal transitionIC TASbiological_process
GO:0010801Negative regulation of peptidyl-threonine phosphorylationIDAbiological_process
GO:0010944Negative regulation of transcription by competitive promoter bindingIDAbiological_process
GO:0016342Catenin complexIDAcellular_component
GO:0017015Regulation of transforming growth factor beta receptor signaling pathwayIC IEAbiological_process
GO:0022409Positive regulation of cell-cell adhesionIDAbiological_process
GO:0030336Negative regulation of cell migrationTASbiological_process
GO:0030509BMP signaling pathwayTASbiological_process
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayIDA TASbiological_process
GO:0030514Negative regulation of BMP signaling pathwayIDA IEAbiological_process
GO:0030617Transforming growth factor beta receptor, inhibitory cytoplasmic mediator activityIDAmolecular_function
GO:0031397Negative regulation of protein ubiquitinationIDAbiological_process
GO:0031398Positive regulation of protein ubiquitinationIDAbiological_process
GO:0031625Ubiquitin protein ligase bindingIEA IPImolecular_function
GO:0032436Positive regulation of proteasomal ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0032925Regulation of activin receptor signaling pathwayIDAbiological_process
GO:0033137Negative regulation of peptidyl-serine phosphorylationIDAbiological_process
GO:0034333Adherens junction assemblyIMPbiological_process
GO:0034616Response to laminar fluid shear stressIEPbiological_process
GO:0034629Cellular protein complex localizationIDAbiological_process
GO:0034713Type I transforming growth factor beta receptor bindingIPImolecular_function
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0043234Protein complexIDA IEAcellular_component
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048185Activin bindingIPImolecular_function
GO:0048844Artery morphogenesisIEA ISSbiological_process
GO:0050821Protein stabilizationIDAbiological_process
GO:0051444Negative regulation of ubiquitin-protein ligase activityIDAbiological_process
GO:0055010Ventricular cardiac muscle tissue morphogenesisIEA ISSbiological_process
GO:0055117Regulation of cardiac muscle contractionIEA ISSbiological_process
GO:0060373Regulation of ventricular cardiac muscle cell membrane depolarizationICbiological_process
GO:0060389Pathway-restricted SMAD protein phosphorylationIEA ISSbiological_process
GO:0060394Negative regulation of pathway-restricted SMAD protein phosphorylationIDA TASbiological_process
GO:0060412Ventricular septum morphogenesisIEA ISSbiological_process
GO:0070411I-SMAD bindingIPImolecular_function
GO:0071560Cellular response to transforming growth factor beta stimulusIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00883332700.04173065230.24168607070.3842519762

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6695657574
GSE13712_SHEARDown-1.2818213679
GSE13712_STATICDown-0.8301569745
GSE19018Down-2.1696890018
GSE19899_A1Up0.8100624770
GSE19899_A2Up1.1221609594
PubMed_21979375_A1Up2.2404242262
PubMed_21979375_A2Up1.6724078368
GSE35957Down-0.3132549212
GSE36640Up1.9495149688
GSE54402Up1.1045215803
GSE9593Down-1.2217790228
GSE43922Up0.5219221885
GSE24585Down-0.1547185374
GSE37065Up0.4044522077
GSE28863_A1Down-0.0257643192
GSE28863_A2Down-0.1825305274
GSE28863_A3Up0.1879345114
GSE28863_A4Up0.0208325553
GSE48662Up0.1087140935

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-217MIMAT0000274MIRT007153Luciferase reporter assayFunctional MTI23471579
hsa-miR-216a-5pMIMAT0000273MIRT007154Luciferase reporter assayFunctional MTI23471579
hsa-miR-25-3pMIMAT0000081MIRT007242Luciferase reporter assayFunctional MTI23435373
hsa-miR-21-5pMIMAT0000076MIRT007362qRT-PCR//Western blotFunctional MTI23292313
hsa-miR-103a-3pMIMAT0000101MIRT027015SequencingFunctional MTI (Weak)20371350
hsa-miR-98-5pMIMAT0000096MIRT027482MicroarrayFunctional MTI (Weak)19088304
hsa-miR-26b-5pMIMAT0000083MIRT028980MicroarrayFunctional MTI (Weak)19088304
hsa-miR-16-5pMIMAT0000069MIRT031521SequencingFunctional MTI (Weak)20371350
hsa-miR-15b-5pMIMAT0000417MIRT046499CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048391CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049511CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.