HCSGD entry for MAOB
1. General information
| Official gene symbol | MAOB |
|---|---|
| Entrez ID | 4129 |
| Gene full name | monoamine oxidase B |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005740 | Mitochondrial envelope | TAS | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | TAS | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0008131 | Primary amine oxidase activity | TAS | molecular_function |
| GO:0009055 | Electron carrier activity | TAS | molecular_function |
| GO:0009636 | Response to toxic substance | IEA | biological_process |
| GO:0010044 | Response to aluminum ion | IEA | biological_process |
| GO:0010269 | Response to selenium ion | IEA | biological_process |
| GO:0014063 | Negative regulation of serotonin secretion | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0032496 | Response to lipopolysaccharide | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045471 | Response to ethanol | IEA | biological_process |
| GO:0045964 | Positive regulation of dopamine metabolic process | IEA | biological_process |
| GO:0050660 | Flavin adenine dinucleotide binding | IEA | molecular_function |
| GO:0051412 | Response to corticosterone | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3603890278 | 0.7177954409 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0199381467 |
| GSE13712_SHEAR | Down | -0.0768249028 |
| GSE13712_STATIC | Down | -0.0434028431 |
| GSE19018 | Up | 0.0954423852 |
| GSE19899_A1 | Up | 0.0941887368 |
| GSE19899_A2 | Down | -0.0158720341 |
| PubMed_21979375_A1 | Down | -0.1929924053 |
| PubMed_21979375_A2 | Up | 0.0831452704 |
| GSE35957 | Down | -0.1192313606 |
| GSE36640 | Up | 0.0006227476 |
| GSE54402 | Up | 0.0112568940 |
| GSE9593 | Down | -0.0583671617 |
| GSE43922 | Up | 0.0178222070 |
| GSE24585 | Down | -0.3377206576 |
| GSE37065 | Up | 0.6160749711 |
| GSE28863_A1 | Down | -0.0564439772 |
| GSE28863_A2 | Up | 0.7059913909 |
| GSE28863_A3 | Up | 0.2683120294 |
| GSE28863_A4 | Up | 0.0384264067 |
| GSE48662 | Up | 0.0261327157 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 8959982 | The drug binds to brain regions with a high MAO-B content, such as the thalamus, the striatum, the cortex, and the brainstem |
| 8959982 | Although not all features of its anti-PD action are known, studies using brain obtained at autopsy from patients who had been treated with 10 mg of selegiline showed that selective inhibition of MAO-B, with the concomitant increase of phenylethylamine and dopamine (DA) but not of serotonin or noradrenaline, in the basal ganglia may be regarded as its mode of action |
| 3731213 | Two forms of monoamine oxidase (MAO A and MAO B) exist which, although similar in a number of properties, can be distinguished on the basis of their substrate specificity, inhibitor sensitivity, kinetic parameters, and protein structure |
| 3731213 | These properties were used to study the molecular mechanism(s) by which glucocorticoid hormones and "aging," known to alter MAO activity in vivo, regulated the expression of MAO A and MAO B in cultured human skin fibroblasts |
| 3731213 | The 6- to 14-fold increases in total activity were paralleled by similar increases in the activity and amount of active MAO A but less than 2- to 3-fold increases in the activity and amount of MAO B |
| 3731213 | Further, our finding that the expression of the two forms of MAO in human fibroblasts can be independently regulated supports the growing evidence that MAO A and MAO B are separate molecular entities |
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