HCSGD entry for MAPT

1. General information

Official gene symbolMAPT
Entrez ID4137
Gene full namemicrotubule-associated protein tau
Other gene symbolsDDPAC FTDP-17 MAPTL MSTD MTBT1 MTBT2 PPND TAU
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000226Microtubule cytoskeleton organizationIDAbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0005200Structural constituent of cytoskeletonTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005874MicrotubuleIEAcellular_component
GO:0005875Microtubule associated complexTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0008017Microtubule bindingIDA IEAmolecular_function
GO:0008088Axon cargo transportIEAbiological_process
GO:0010506Regulation of autophagyIGIbiological_process
GO:0017124SH3 domain bindingIPImolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0030424AxonIDAcellular_component
GO:0030426Growth coneIDAcellular_component
GO:0031113Regulation of microtubule polymerizationNASbiological_process
GO:0031116Positive regulation of microtubule polymerizationIDAbiological_process
GO:0032387Negative regulation of intracellular transportIEAbiological_process
GO:0034185Apolipoprotein bindingIPImolecular_function
GO:0034399Nuclear peripheryIDAcellular_component
GO:0045298Tubulin complexIDAcellular_component
GO:0045773Positive regulation of axon extensionIDAbiological_process
GO:0047497Mitochondrion transport along microtubuleIEAbiological_process
GO:0048675Axon extensionIEAbiological_process
GO:0048699Generation of neuronsNASbiological_process
GO:0060632Regulation of microtubule-based movementIEAbiological_process
GO:0071813Lipoprotein particle bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.81387432850.77638959770.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0273072251
GSE13712_SHEARDown-0.1567360246
GSE13712_STATICUp0.0760825371
GSE19018Up0.0959541519
GSE19899_A1Down-0.0344284387
GSE19899_A2Up0.0988883992
PubMed_21979375_A1Down-0.0457851765
PubMed_21979375_A2Down-0.0669121791
GSE35957Up0.0438846335
GSE36640Up0.0273263728
GSE54402Down-0.0177343762
GSE9593Up0.0594901567
GSE43922Up0.0224304874
GSE24585Down-0.1866549802
GSE37065Down-0.1390768075
GSE28863_A1Down-0.0287206147
GSE28863_A2Up0.1666604772
GSE28863_A3Up0.3064113841
GSE28863_A4Up0.1115741834
GSE48662Down-0.0669326410

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DocetaxelDB01248 APRD00932

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34c-5pMIMAT0000686MIRT007189Luciferase reporter assayFunctional MTI23423488
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.