HCSGD entry for MAT2A
1. General information
| Official gene symbol | MAT2A |
|---|---|
| Entrez ID | 4144 |
| Gene full name | methionine adenosyltransferase II, alpha |
| Other gene symbols | MATA2 MATII SAMS2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000096 | Sulfur amino acid metabolic process | TAS | biological_process |
| GO:0004478 | Methionine adenosyltransferase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006556 | S-adenosylmethionine biosynthetic process | IEA | biological_process |
| GO:0006730 | One-carbon metabolic process | IEA | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0032259 | Methylation | TAS | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9485714790 | 0.0230456290 | 0.9999902473 | 0.2920481464 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4120591802 |
| GSE13712_SHEAR | Up | 0.1053368928 |
| GSE13712_STATIC | Down | -0.0776747954 |
| GSE19018 | Down | -1.3609432719 |
| GSE19899_A1 | Down | -0.6983242602 |
| GSE19899_A2 | Down | -0.4907653531 |
| PubMed_21979375_A1 | Down | -0.6134561787 |
| PubMed_21979375_A2 | Down | -1.1897801937 |
| GSE35957 | Down | -0.0564901682 |
| GSE36640 | Down | -0.7722207664 |
| GSE54402 | Up | 0.1175488616 |
| GSE9593 | Up | 0.1200136826 |
| GSE43922 | Up | 0.1457708802 |
| GSE24585 | Up | 0.0355010320 |
| GSE37065 | Down | -0.0663771834 |
| GSE28863_A1 | Up | 0.0392998007 |
| GSE28863_A2 | Up | 0.3227441388 |
| GSE28863_A3 | Down | -0.3426649276 |
| GSE28863_A4 | Down | -0.1023792738 |
| GSE48662 | Down | -0.0098021792 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005213 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016409 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029216 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042675 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042847 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-326 | MIMAT0000756 | MIRT043644 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044305 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044919 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045753 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
