HCSGD entry for MC1R

1. General information

Official gene symbolMC1R
Entrez ID4157
Gene full namemelanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Other gene symbolsCMM5 MSH-R SHEP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004977Melanocortin receptor activityTASmolecular_function
GO:0004980Melanocyte-stimulating hormone receptor activityIEA IPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDA IEA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerTASbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0008528G-protein coupled peptide receptor activityTASmolecular_function
GO:0009650UV protectionTASbiological_process
GO:0010739Positive regulation of protein kinase A signalingISSbiological_process
GO:0015630Microtubule cytoskeletonIDAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0019233Sensory perception of painIEAbiological_process
GO:0030819Positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0032720Negative regulation of tumor necrosis factor productionIMPbiological_process
GO:0035556Intracellular signal transductionISSbiological_process
GO:0042438Melanin biosynthetic processIEAbiological_process
GO:0043473PigmentationTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0051897Positive regulation of protein kinase B signalingISSbiological_process
GO:0070914UV-damage excision repairIDAbiological_process
GO:0090037Positive regulation of protein kinase C signalingISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.33734769580.64110872310.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0141239502
GSE13712_SHEARDown-0.3262516661
GSE13712_STATICUp0.1638680944
GSE19018Down-0.1525076304
GSE19899_A1Down-0.0070256115
GSE19899_A2Down-0.0534741896
PubMed_21979375_A1Up0.6613945762
PubMed_21979375_A2Up0.0653808713
GSE35957Down-0.3467518213
GSE36640Down-0.0920597666
GSE54402Down-0.0423551220
GSE9593Up0.0352950938
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.4864032221
GSE28863_A2Up0.1757091997
GSE28863_A3Up0.3866253494
GSE28863_A4Up0.0120694486
GSE48662Down-0.0662295088

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AfamelanotideDB04931 -
CZEN 002DB05479 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.