HCSGD entry for ADAM11
1. General information
| Official gene symbol | ADAM11 |
|---|---|
| Entrez ID | 4185 |
| Gene full name | ADAM metallopeptidase domain 11 |
| Other gene symbols | MDC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004222 | Metalloendopeptidase activity | IEA | molecular_function |
| GO:0005178 | Integrin binding | TAS | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | IEA TAS | biological_process |
| GO:0008237 | Metallopeptidase activity | TAS | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0031012 | Extracellular matrix | ISS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8790152388 | 0.4366426504 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0323626436 |
| GSE13712_SHEAR | Down | -0.2287886372 |
| GSE13712_STATIC | Down | -0.0078471582 |
| GSE19018 | Down | -0.0444800924 |
| GSE19899_A1 | Down | -0.0936185050 |
| GSE19899_A2 | Down | -0.0845609132 |
| PubMed_21979375_A1 | Down | -0.0070373736 |
| PubMed_21979375_A2 | Down | -0.0229882071 |
| GSE35957 | Down | -0.0110557652 |
| GSE36640 | Up | 0.0423217470 |
| GSE54402 | Up | 0.0594132654 |
| GSE9593 | Up | 0.0841486942 |
| GSE43922 | Up | 0.0365754943 |
| GSE24585 | Up | 0.1095023397 |
| GSE37065 | Down | -0.1168674079 |
| GSE28863_A1 | Down | -0.1924781934 |
| GSE28863_A2 | Down | -0.1193597978 |
| GSE28863_A3 | Up | 0.4378723235 |
| GSE28863_A4 | Up | 0.1132729670 |
| GSE48662 | Down | -0.6190558743 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
