HCSGD entry for MDH1
1. General information
| Official gene symbol | MDH1 |
|---|---|
| Entrez ID | 4190 |
| Gene full name | malate dehydrogenase 1, NAD (soluble) |
| Other gene symbols | MDH-s MDHA MGC:1375 MOR2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004470 | Malic enzyme activity | TAS | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | IEA TAS | biological_process |
| GO:0006006 | Glucose metabolic process | TAS | biological_process |
| GO:0006094 | Gluconeogenesis | TAS | biological_process |
| GO:0006099 | Tricarboxylic acid cycle | IEA | biological_process |
| GO:0006107 | Oxaloacetate metabolic process | IEA | biological_process |
| GO:0006108 | Malate metabolic process | IEA | biological_process |
| GO:0006734 | NADH metabolic process | IEA | biological_process |
| GO:0016615 | Malate dehydrogenase activity | IEA | molecular_function |
| GO:0016616 | Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IEA | molecular_function |
| GO:0030060 | L-malate dehydrogenase activity | IEA TAS | molecular_function |
| GO:0044262 | Cellular carbohydrate metabolic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047860 | Diiodophenylpyruvate reductase activity | IEA | molecular_function |
| GO:0051287 | NAD binding | IEA | molecular_function |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7826099996 | 0.3842493484 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2914818231 |
| GSE13712_SHEAR | Down | -0.0901615179 |
| GSE13712_STATIC | Up | 0.0606037462 |
| GSE19018 | Up | 0.2491312150 |
| GSE19899_A1 | Down | -0.0015115758 |
| GSE19899_A2 | Down | -0.0380862858 |
| PubMed_21979375_A1 | Down | -0.2400067888 |
| PubMed_21979375_A2 | Down | -0.1436533283 |
| GSE35957 | Down | -0.1358135221 |
| GSE36640 | Down | -0.1978142348 |
| GSE54402 | Down | -0.0784459707 |
| GSE9593 | Down | -0.0807881906 |
| GSE43922 | Down | -0.0026266284 |
| GSE24585 | Down | -0.1431803177 |
| GSE37065 | Down | -0.0295989148 |
| GSE28863_A1 | Up | 0.1266879437 |
| GSE28863_A2 | Up | 0.6290704414 |
| GSE28863_A3 | Down | -0.2919760933 |
| GSE28863_A4 | Down | -0.1733515011 |
| GSE48662 | Down | -0.2369759081 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Compound | Target | Confidence score | Uniprot |
|---|---|---|---|
| CHEMBL808 | CHEMBL3560 | 4 | P40925 |
| CHEMBL593 | CHEMBL3560 | 4 | P40925 |
| CHEMBL104 | CHEMBL3560 | 4 | P40925 |
| CHEMBL1221 | CHEMBL3560 | 4 | P40925 |
| CHEMBL1484 | CHEMBL3560 | 4 | P40925 |
| CHEMBL91 | CHEMBL3560 | 4 | P40925 |
Entries Per Page
Displaying Page of
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| 2'-Monophosphoadenosine 5'-Diphosphoribose | DB03461 | EXPT02293 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028752 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045287 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046497 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22971926 | Here, we show that MDH1 plays a critical role in the cellular senescence of human fibroblasts |
| 22971926 | Knockdown of MDH1 in young HDFs (PD 20) and the IMR90 human fibroblast cell line resulted in the appearance of significant cellular senescence features, including senescence-associated beta-galactosidase staining, flattened and enlarged morphology, increased population doubling time, and elevated p16(INK4A) and p21(CIP1) protein levels |
| 22971926 | Cytosolic NAD/NADH ratios were decreased in old HDFs to the same extent as in MDH1 knockdown HDFs, suggesting that cytosolic NAD depletion is related to cellular senescence |
| 22971926 | These results indicate that the decrease in MDH1 and subsequent reduction in NAD/NADH ratio, which causes SIRT1 inhibition, is a likely carbohydrate metabolism-controlled cellular senescence mechanism |
Entries Per Page
Displaying Page of
