HCSGD entry for MDK
1. General information
| Official gene symbol | MDK |
|---|---|
| Entrez ID | 4192 |
| Gene full name | midkine (neurite growth-promoting factor 2) |
| Other gene symbols | ARAP MK NEGF2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001662 | Behavioral fear response | IEA | biological_process |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0007399 | Nervous system development | NAS | biological_process |
| GO:0007614 | Short-term memory | IEA | biological_process |
| GO:0008083 | Growth factor activity | IEA NAS | molecular_function |
| GO:0008201 | Heparin binding | IDA | molecular_function |
| GO:0009611 | Response to wounding | IEA ISS | biological_process |
| GO:0016477 | Cell migration | IEA | biological_process |
| GO:0021542 | Dentate gyrus development | IEA | biological_process |
| GO:0021681 | Cerebellar granular layer development | IEA | biological_process |
| GO:0021987 | Cerebral cortex development | IEA | biological_process |
| GO:0030154 | Cell differentiation | NAS | biological_process |
| GO:0030325 | Adrenal gland development | IEA ISS | biological_process |
| GO:0030421 | Defecation | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0050795 | Regulation of behavior | IEA | biological_process |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
| GO:0051781 | Positive regulation of cell division | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9800394400 | 0.0001383496 | 0.9999902473 | 0.0206355932 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4555093858 |
| GSE13712_SHEAR | Down | -0.1817871067 |
| GSE13712_STATIC | Up | 0.0397408556 |
| GSE19018 | Down | -0.6822670158 |
| GSE19899_A1 | Down | -2.1661606854 |
| GSE19899_A2 | Down | -2.8395916831 |
| PubMed_21979375_A1 | Down | -2.2943125623 |
| PubMed_21979375_A2 | Down | -4.0472050999 |
| GSE35957 | Down | -2.4285098835 |
| GSE36640 | Down | -1.8863180402 |
| GSE54402 | Down | -0.6395035118 |
| GSE9593 | Down | -1.4418479371 |
| GSE43922 | Down | -0.8499927363 |
| GSE24585 | Up | 0.3817149531 |
| GSE37065 | Up | 0.3704304073 |
| GSE28863_A1 | Down | -0.4815508698 |
| GSE28863_A2 | Down | -0.4276428491 |
| GSE28863_A3 | Up | 0.0936252781 |
| GSE28863_A4 | Up | 0.0389431525 |
| GSE48662 | Down | -0.6958594048 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022440 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036299 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040730 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050887 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
