HCSGD entry for MEF2A

1. General information

Official gene symbolMEF2A
Entrez ID4205
Gene full namemyocyte enhancer factor 2A
Other gene symbolsADCAD1 RSRFC4 RSRFC9 mef2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000002Mitochondrial genome maintenanceIEA ISSbiological_process
GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000165MAPK cascadeIDA IEAbiological_process
GO:0000790Nuclear chromatinIEA ISScellular_component
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIDA IEAmolecular_function
GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityIDAmolecular_function
GO:0000987Core promoter proximal region sequence-specific DNA bindingIEAmolecular_function
GO:0001046Core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001085RNA polymerase II transcription factor bindingIPImolecular_function
GO:0001105RNA polymerase II transcription coactivator activityIDAmolecular_function
GO:0001568Blood vessel developmentIEAbiological_process
GO:0001649Osteoblast differentiationIEAbiological_process
GO:0001782B cell homeostasisIEAbiological_process
GO:0001947Heart loopingIEAbiological_process
GO:0001958Endochondral ossificationIEAbiological_process
GO:0001974Blood vessel remodelingIEAbiological_process
GO:0002062Chondrocyte differentiationIEAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002467Germinal center formationIEAbiological_process
GO:0002634Regulation of germinal center formationIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0003138Primary heart field specificationIEAbiological_process
GO:0003139Secondary heart field specificationIEAbiological_process
GO:0003151Outflow tract morphogenesisIEAbiological_process
GO:0003185Sinoatrial valve morphogenesisIEAbiological_process
GO:0003211Cardiac ventricle formationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIDA IEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0006351Transcription, DNA-templatedIDA IEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0006959Humoral immune responseIEAbiological_process
GO:0007507Heart developmentIEPbiological_process
GO:0007517Muscle organ developmentNASbiological_process
GO:0007519Skeletal muscle tissue developmentIEAbiological_process
GO:0007521Muscle cell fate determinationIEAbiological_process
GO:0007611Learning or memoryIEAbiological_process
GO:0010613Positive regulation of cardiac muscle hypertrophyIEAbiological_process
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0010694Positive regulation of alkaline phosphatase activityIEAbiological_process
GO:0014033Neural crest cell differentiationIEAbiological_process
GO:0014898Cardiac muscle hypertrophy in response to stressIEAbiological_process
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0021542Dentate gyrus developmentIEAbiological_process
GO:0030017SarcomereIEAcellular_component
GO:0030220Platelet formationIEAbiological_process
GO:0030224Monocyte differentiationIEAbiological_process
GO:0030318Melanocyte differentiationIEAbiological_process
GO:0030501Positive regulation of bone mineralizationIEAbiological_process
GO:0030890Positive regulation of B cell proliferationIEAbiological_process
GO:0033197Response to vitamin EIEAbiological_process
GO:0033613Activating transcription factor bindingIEA IPImolecular_function
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035035Histone acetyltransferase bindingIPImolecular_function
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035690Cellular response to drugIEAbiological_process
GO:0035984Cellular response to trichostatin AIEAbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042100B cell proliferationIEAbiological_process
GO:0042692Muscle cell differentiationTASbiological_process
GO:0042826Histone deacetylase bindingIEA IPImolecular_function
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043565Sequence-specific DNA bindingIDA IEAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045652Regulation of megakaryocyte differentiationIEAbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046332SMAD bindingIPImolecular_function
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048311Mitochondrion distributionIEA ISSbiological_process
GO:0048666Neuron developmentIEAbiological_process
GO:0048703Embryonic viscerocranium morphogenesisIEAbiological_process
GO:0048813Dendrite morphogenesisISSbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
GO:0050853B cell receptor signaling pathwayIEAbiological_process
GO:0051145Smooth muscle cell differentiationIEAbiological_process
GO:0051149Positive regulation of muscle cell differentiationTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0055005Ventricular cardiac myofibril assemblyIEA ISSbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060025Regulation of synaptic activityIEAbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationIEAbiological_process
GO:0060297Regulation of sarcomere organizationIEAbiological_process
GO:0060536Cartilage morphogenesisIEAbiological_process
GO:0061337Cardiac conductionIEA ISSbiological_process
GO:0070375ERK5 cascadeIMPbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071277Cellular response to calcium ionIDA IEAbiological_process
GO:0071300Cellular response to retinoic acidIEAbiological_process
GO:0071333Cellular response to glucose stimulusIEAbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
GO:0071498Cellular response to fluid shear stressIEAbiological_process
GO:0071837HMG box domain bindingIEAmolecular_function
GO:0071864Positive regulation of cell proliferation in bone marrowIEAbiological_process
GO:0072102Glomerulus morphogenesisIEAbiological_process
GO:0072160Nephron tubule epithelial cell differentiationIEAbiological_process
GO:0090073Positive regulation of protein homodimerization activityIEAbiological_process
GO:2000111Positive regulation of macrophage apoptotic processIEAbiological_process
GO:2000727Positive regulation of cardiac muscle cell differentiationIEAbiological_process
GO:2000987Positive regulation of behavioral fear responseIEAbiological_process
GO:2001013Epithelial cell proliferation involved in renal tubule morphogenesisIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.32421858970.42627748950.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3739966061
GSE13712_SHEARDown-0.0273697951
GSE13712_STATICDown-0.0898480670
GSE19018Down-0.3264697037
GSE19899_A1Up0.0276989983
GSE19899_A2Up0.0677069033
PubMed_21979375_A1Down-0.2159774196
PubMed_21979375_A2Up0.1479199677
GSE35957Up0.7798003552
GSE36640Down-0.0413487684
GSE54402Down-0.3463940994
GSE9593Up0.2782200334
GSE43922Down-0.0428594523
GSE24585Up0.5205071851
GSE37065Up0.2700799207
GSE28863_A1Up0.0107163907
GSE28863_A2Up0.2804165050
GSE28863_A3Down-0.1382808097
GSE28863_A4Up0.0666510886
GSE48662Up0.1037682031

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT000391Luciferase reporter assayFunctional MTI19188439
hsa-miR-1MIMAT0000416MIRT000391qRT-PCRFunctional MTI (Weak)21169019
hsa-miR-335-5pMIMAT0000765MIRT016730MicroarrayFunctional MTI (Weak)18185580
hsa-miR-155-5pMIMAT0000646MIRT020561Reporter assay;OtherFunctional MTI20584899
hsa-miR-132-3pMIMAT0000426MIRT021772MicroarrayFunctional MTI (Weak)17612493
hsa-miR-21-5pMIMAT0000076MIRT030700MicroarrayFunctional MTI (Weak)18591254
hsa-miR-30a-3pMIMAT0000088MIRT049911CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25655189Myocyte enhancer factor 2A (MEF2A) is involved in vascular smooth muscle cell (VSMC) proliferation, migration, and senescence
25655189MicroRNA-143/145 (miR-143/145), which may be regulated by MEF2A, is known to promote cellular senescence
25655189We hypothesized that MEF2A may promote VSMC senescence via miR-143/145
25655189The MEF2A protein, mRNA, and miR-143/145 levels in VSMCs were detected using Western blot analysis and SYBR green real-time quantitative PCR, respectively
25655189We further manipulated the expression levels of MEF2A and miR-143 through viral or transient transfection
25655189MEF2A knockdown or miR-143 inhibitor suppressed cellular senescence and increased proliferation and migration
25655189We further revealed AKT signaling as a potential miR-143 target, and an induction of miR-143 expression by MEF2A via KLF2
25655189Additionally, overexpression of MEF2A and miR-143 resulted in synergistic effects on promotion of senescence, and MEF2A knockdown and miR-143 reduction by inhibitor had synergistic inhibitory effects
25655189Our results revealed a link and interaction between MEF2A and miR-143 and suggested a potential mechanism for MEF2A to regulate H(2)O(2) -induced VSMC senescence
Entries Per Page
Displaying Page of