HCSGD entry for MGMT
1. General information
| Official gene symbol | MGMT |
|---|---|
| Entrez ID | 4255 |
| Gene full name | O-6-methylguanine-DNA methyltransferase |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003908 | Methylated-DNA-[protein]-cysteine S-methyltransferase activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006266 | DNA ligation | TAS | biological_process |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006306 | DNA methylation | TAS | biological_process |
| GO:0006307 | DNA dealkylation involved in DNA repair | IEA | biological_process |
| GO:0008168 | Methyltransferase activity | TAS | molecular_function |
| GO:0009008 | DNA-methyltransferase activity | TAS | molecular_function |
| GO:0009636 | Response to toxic substance | IEA | biological_process |
| GO:0034599 | Cellular response to oxidative stress | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043281 | Regulation of cysteine-type endopeptidase activity involved in apoptotic process | IEA | biological_process |
| GO:0045471 | Response to ethanol | IEA | biological_process |
| GO:0045739 | Positive regulation of DNA repair | IEA | biological_process |
| GO:0051593 | Response to folic acid | IEA | biological_process |
| GO:0060548 | Negative regulation of cell death | IEA | biological_process |
| GO:0060644 | Mammary gland epithelial cell differentiation | IEA | biological_process |
| GO:0071407 | Cellular response to organic cyclic compound | IEA | biological_process |
| GO:0071479 | Cellular response to ionizing radiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9967479959 | 0.0010029976 | 0.9999902473 | 0.0598475113 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4075209382 |
| GSE13712_SHEAR | Down | -2.1740021316 |
| GSE13712_STATIC | Down | -2.5801726186 |
| GSE19018 | Down | -0.0455116864 |
| GSE19899_A1 | Down | -0.7357583919 |
| GSE19899_A2 | Down | -1.2528845454 |
| PubMed_21979375_A1 | Down | -1.0624060609 |
| PubMed_21979375_A2 | Down | -1.5127195630 |
| GSE35957 | Down | -0.1424461668 |
| GSE36640 | Down | -0.9819070795 |
| GSE54402 | Down | -0.8023102472 |
| GSE9593 | Down | -0.0941106769 |
| GSE43922 | Down | -0.4976623211 |
| GSE24585 | Down | -0.1288859586 |
| GSE37065 | Down | -0.1990949459 |
| GSE28863_A1 | Down | -0.0561263900 |
| GSE28863_A2 | Down | -0.1407558324 |
| GSE28863_A3 | Up | 0.0771429944 |
| GSE28863_A4 | Up | 0.0204360655 |
| GSE48662 | Up | 0.1547710629 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Cysteine | DB00151 | NUTR00018 | DB04443 |
| S-Methylcysteine | DB02216 | EXPT01076 | EXPT02919 |
| Benzylcysteine | DB04531 | EXPT00643 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-181d-5p | MIMAT0002821 | MIRT006937 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22570426 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24265816 | The sensitivity of glioblastoma cells to TMZ is interfered by many factors, such as the expression of O-6-methylguanine-DNA methyltransferase (MGMT) and activation of AKT signaling |
| 24265816 | The sensitivity of GBM cells to TMZ was primarily determined by the expression of MGMT |
| 24265816 | To omit the effect of MGMT, we concentrated on the cell lines devoid of expression of MGMT |
| 23383259 | All these effects were completely abrogated in isogenic glioma cells expressing O(6)-methylguanine-DNA methyltransferase (MGMT), indicating that a single type of DNA lesion, O(6)-methylguanine (O(6)MeG), is able to trigger all these responses |
| 10454622 | Logarithmically growing normal human fibro-blasts (NHF) displayed little (0-15%) CpG methylation in select regions of three CpG islands [estrogen receptor (ER), E-cadherin (ECAD) and O (6)-methylguanine-DNA methyltransferase (MGMT)] examined |
| 10454622 | These confluent, growth-arrested cells, however, displayed extensive ( approximately 50%) methylation of the MGMT CpG island |
| 10454622 | CpG methylation in the MGMT CpG island was not associated with cellular senescence |
| 10454622 | The methylation was, however, heritable, but not permanent, as the level of CpG methylation in the MGMT CpG island of cells 4 population doublings following replating after confluence were no different from those in confluent cultures, but returned to levels noted in logarithmically growing cells by 10 population doublings following replating |
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