HCSGD entry for CIITA

1. General information

Official gene symbolCIITA
Entrez ID4261
Gene full nameclass II, major histocompatibility complex, transactivator
Other gene symbolsC2TA CIITAIV MHC2TA NLRA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEA IMPbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0006955Immune responseTASbiological_process
GO:0007568AgingIEAbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0009986Cell surfaceIEAcellular_component
GO:0016605PML bodyIDAcellular_component
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0032403Protein complex bindingIDAmolecular_function
GO:0032966Negative regulation of collagen biosynthetic processICbiological_process
GO:0033613Activating transcription factor bindingIPImolecular_function
GO:0034341Response to interferon-gammaIDAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045345Positive regulation of MHC class I biosynthetic processIDAbiological_process
GO:0045348Positive regulation of MHC class II biosynthetic processIC IEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEA IMPbiological_process
GO:0046677Response to antibioticIDAbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0071257Cellular response to electrical stimulusIEAbiological_process
GO:0071346Cellular response to interferon-gammaIEAbiological_process
GO:0071360Cellular response to exogenous dsRNAIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.71297307850.81637752370.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0568305704
GSE13712_SHEARUp0.0795031319
GSE13712_STATICDown-0.0900193198
GSE19018Up0.1705738819
GSE19899_A1Up0.0146461062
GSE19899_A2Up0.1641861129
PubMed_21979375_A1Up0.3021244952
PubMed_21979375_A2Down-0.0304398640
GSE35957Up0.0302207534
GSE36640Up0.1352678397
GSE54402Up0.1124971566
GSE9593Up0.1025846056
GSE43922Up0.0244026174
GSE24585Down-0.0440298085
GSE37065Up0.0292054970
GSE28863_A1Down-0.0450781531
GSE28863_A2Down-0.0945081523
GSE28863_A3Up0.2112991724
GSE28863_A4Down-0.0950476156
GSE48662Down-0.1330714223

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019135MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.